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Cognition

HistamineEvidence & Dosage

Wakefulness, allergy, histamine intolerance and brain fog.

Evidence at a glance

Total studies
463
With abstract
46
Meta / Systematic / RCT
0
Highly cited
21
Publication years
1952–2026

Histamine in the context of Cognition

This topic is part of our "Cognition" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Histamine

Ranked by influential-citation count and publication year.

  1. Auto-inhibition of brain histamine release mediated by a novel class (H3) of histamine receptor.

    Nature1983200 influential citations

    Although histaminergic neurones have not yet been histochemically visualized, there is little doubt that histamine (HA) has a neurotransmitter role in the invertebrate and mammalian central nervous system. For example, a combination of…

  2. Histamine H3 receptors and sleep-wake regulation.

    The Journal of pharmacology and experimental therapeutics201136 influential citations

    The histaminergic system fulfills a major role in the maintenance of waking. Histaminergic neurons are located exclusively in the posterior hypothalamus from where they project to most areas of the central nervous system. The histamine…

  3. Histamine Intolerance: The Current State of the Art

    Biomolecules202021 influential citations

    Histamine intolerance, also referred to as enteral histaminosis or sensitivity to dietary histamine, is a disorder associated with an impaired ability to metabolize ingested histamine that was described at the beginning of the 21st…

  4. Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.

    Gastroenterology2016n=2815 influential citations

    <h4>Background & aims</h4>Histamine sensitizes the nociceptor transient reporter potential channel V1 (TRPV1) and has been shown to contribute to visceral hypersensitivity in animals. We investigated the role of TRPV1 in irritable bowel…

  5. The shape of the dose-response curve to histamine in asthmatic and normal subjects.

    American Review of Respiratory Disease201513 influential citations

    In order to determine the shape of the dose-response curves of the human airways to bronchial challenge, changes in forced expiratory volume in one second (FEV1) after inhaled histamine were measured in 8 current asthmatic, 2 mildly…

  6. The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets

    Frontiers in Immunology201812 influential citations

    Histamine and its receptors (H1R-H4R) play a crucial and significant role in the development of various allergic diseases. Mast cells are multifunctional bone marrow-derived tissue-dwelling cells that are the major producer of histamine in…

  7. Histamine, histamine intoxication and intolerance.

    Allergologia et Immunopathologia201512 influential citations

    Excessive accumulation of histamine in the body leads to miscellaneous symptoms mediated by its bond to corresponding receptors (H1-H4). Increased concentration of histamine in blood can occur in healthy individuals after ingestion of…

  8. Histamine, histamine receptors and their role in immune pathology

    Clinical and Experimental Allergy200911 influential citations

    The important roles of histamine in body physiology and various pathologic events have been well established, whereas new and exciting findings are still being uncovered. Histamine is not only the major mediator of the acute inflammatory…

  9. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1

    Cancer Cell20219 influential citations

    Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective analyses revealed that cancer patients who took antihistamines during immunotherapy treatment had significantly improved survival. We uncovered that…

  10. Histamine (Scombroid) Fish Poisoning: a Comprehensive Review

    Clinical reviews in allergy and immunology20168 influential citations

    Histamine fish poisoning, also known as scombroid poisoning, is the most common cause of ichythyotoxicosis worldwide and results from the ingestion of histamine-contaminated fish in the Scombroidae and Scomberesocidae families, including…

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