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Longevity

SenolyticsEvidence & Dosage

Fisetin, quercetin, dasatinib — clearing senescent cells, intermittent protocols.

Evidence at a glance

Total studies
971
With abstract
47
Meta / Systematic / RCT
0
Highly cited
31
Publication years
1987–2026

Senolytics in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Senolytics

Ranked by influential-citation count and publication year.

  1. Therapy-induced senescence in cancer.

    Journal of the National Cancer Institute2010148 influential citations

    Cellular senescence is a response to nonlethal stress that results in persistent cytostasis with a distinct morphological and biochemical phenotype. The senescence phenotype, detected in tumors through the expression of mRNA and protein…

  2. Targeting Cellular Senescence for Healthy Aging: Advances in Senolytics and Senomorphics.

    Drug Des Devel Ther2025n=261review68 influential citations

    BACKGROUND: Cellular senescence is a fundamental characteristic of aging, marked by permanent cell cycle cessation and the release of pro-inflammatory mediators. Although senescence plays advantageous roles in tissue regeneration and tumor…

  3. Senescence landscape in the liver following sepsis and senolytics as potential therapeutics

    Aging Cell202461 influential citations

    Senescence, caused by cell-cycle arrest, is a hallmark of aging. Senescence has also been described in embryogenesis, wound healing, and acute injuries. Sepsis is characterized by a dysregulated host response to infection, leading to organ…

  4. Supramolecular Senolytics via Intracellular Oligomerization of Peptides in Response to Elevated Reactive Oxygen Species Levels in Aging Cells

    Journal of the American Chemical Society202346 influential citations

    Senolytics, which eliminate senescent cells from tissues, represent an emerging therapeutic strategy for various age-related diseases. Most senolytics target antiapoptotic proteins, which are overexpressed in senescent cells, limiting…

  5. Targeting senescence with radioactive 223Ra/Ba SAzymes enables senolytics-unlocked One‐Two punch strategy to boost anti-tumor immunotherapy

    Biomaterials202542 influential citations

    Senescent cells are characterized by a persistent cessation of their cell cycle, rendering them valuable targets for anti-tumor strategies in cancer treatment. Numerous studies have explored induced senescence as a promising approach in…

  6. Senolytics cocktail dasatinib and quercetin alleviate chondrocyte senescence and facet joint osteoarthritis in mice

    The Spine Journal202541 influential citations

    <h4>Background context</h4>Low back pain (LBP) is a pervasive issue, causing substantial economic burden and physical distress worldwide. Facet joint osteoarthritis (FJ OA) is believed to be a significant contributor to this problem.…

  7. Immunotherapy and senolytics in head and neck squamous cell carcinoma: phase 2 trial results

    Nature Medicine2025n=5140 influential citations

    Recent advancements in cancer immunotherapy have improved patient outcomes, yet responses to immunotherapy remain moderate. Immunosenescence has been shown to contribute to the development and progression of various diseases; however, its…

  8. The Differential Effect of Senolytics on SASP Cytokine Secretion and Regulation of EMT by CAFs

    International Journal of Molecular Sciences202437 influential citations

    The tumor microenvironment (TME) plays an essential role in tumor progression and in modulating tumor response to anticancer therapy. Cellular senescence leads to a switch in the cell secretome, characterized by the senescence-associated…

  9. Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence

    Cells202437 influential citations

    Oxidative stress is a prominent causal factor in the premature senescence of microvascular endothelial cells and the ensuing blood-brain barrier (BBB) dysfunction. Through the exposure of an in vitro model of human BBB, composed of brain…

  10. NK‐Cell‐Derived Extracellular Vesicles Engineered to Carry Senolytics Eliminate Chemotherapy‐Induced Senescent Osteosarcoma Cells

    Journal of Extracellular Vesicles202535 influential citations

    Osteosarcoma (OS) is a type of bone tumour characterized by high risk of metastatic progression and recurrence after therapy. Traditional tumour treatment methods such as radiotherapy and chemotherapy can lead to the accumulation of…

Frequently asked

What dosage was studied?
• Senolytics and senomorphics targeting cellular senescence (Not applicable; review summarizes reported doses including D+Q 100 mg/day dasatinib + 1000 mg/day quercetin for 3 days/month and fisetin 20–100 mg/kg PO in mice)
Are there safety considerations for Senolytics?
• Navitoclax may cause thrombocytopenia. • Senolytics may cause immune suppression and infections. • Potential off-target apoptosis in healthy cells. • Long-term repeated dosing could disrupt tissue homeostasis.

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