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Longevity

Time-Restricted EatingEvidence & Dosage

8/16 or similar — autophagic and metabolic effects.

Evidence at a glance

Total studies
565
With abstract
45
Meta / Systematic / RCT
22
Highly cited
50
Publication years
1982–2026

Time-Restricted Eating in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Time-Restricted Eating

Ranked by influential-citation count and publication year.

  1. Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial.

    JAMA Intern Med2022n=90Study200 influential citations

    IMPORTANCE: It is unclear how effective intermittent fasting is for losing weight and body fat, and the effects may depend on the timing of the eating window. This randomized trial compared time-restricted eating (TRE) with eating over a…

  2. Time-restricted eating: Watching the clock to treat obesity.

    Cell Metab2024n=65review191 influential citations

    Time-restricted eating (TRE) has become a popular strategy to treat obesity. TRE involves confining the eating window to 4-10 h per day and fasting for the remaining hours (14-20 h fast). During the eating window, individuals are…

  3. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults.

    The American journal of clinical nutrition2009139 influential citations

    <h4>Background</h4>Rodent studies show that oligofructose promotes weight loss, stimulates satiety hormone secretion, reduces energy intake, and improves lipid profiles.<h4>Objective</h4>Our objective was to examine the effects of…

  4. Intermittent fasting plus early time-restricted eating versus calorie restriction and standard care in adults at risk of type 2 diabetes: a randomized controlled trial.

    Nat Med2023n=209RCT122 influential citations

    Intermittent fasting appears an equivalent alternative to calorie restriction (CR) to improve health in humans. However, few trials have considered applying meal timing during the 'fasting' day, which may be a limitation. We developed a…

  5. Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.

    Ann Intern Med2024n=108rct93 influential citations

    BACKGROUND: Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits. OBJECTIVE: To determine the effects of TRE as a lifestyle…

  6. The effects of time-restricted eating versus habitual diet on inflammatory cytokines and adipokines in the general adult population: a systematic review with meta-analysis.

    The American journal of clinical nutrition2024n=93683 influential citations

    <h4>Background</h4>Time-restricted eating (TRE) may facilitate weight loss, but its impact on inflammation remains unclear. Chronic inflammation can detrimentally increase risk of obesity-associated comorbidities.<h4>Objectives</h4>The aim…

  7. The Effect of Early Time-Restricted Eating vs Later Time-Restricted Eating on Weight Loss and Metabolic Health.

    J Clin Endocrinol Metab2023n=730Meta-Analysis81 influential citations

    Context It remains controversial whether the choice of the daily eating window early or later in time-restricted eating (TRE) intervention (early or later TRE) has different effects on weight loss and metabolic health. Objective A network…

  8. Effects of 3 months of 10-h per-day time-restricted eating and 3 months of follow-up on bodyweight and cardiometabolic health in Danish individuals at high risk of type 2 diabetes: the RESET single-centre, parallel, superiority, open-label, randomised controlled trial.

    The lancet. Healthy longevity2024n=10071 influential citations

    <h4>Background</h4>Time-restricted eating (TRE) has been suggested to be a simple, feasible, and effective dietary strategy for individuals with overweight or obesity. We aimed to investigate the effects of 3 months of 10-h per-day TRE and…

  9. Metabolic Efficacy of Time-Restricted Eating in Adults: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    J Clin Endocrinol Metab2022n=899Meta-Analysis67 influential citations

    Context Time-restricted eating (TRE), which restricts food intake to a limited duration of the day, is a key regimen of intermittent fasting. Objective The aim of our study was to provide an up-to-date meta-analysis and systematic review…

    Finding: In overweight participants, time-restricted eating improved triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels.

  10. Time-restricted eating, caloric reduction, and unrestricted eating effects on weight and metabolism: a randomized trial.

    Obesity (Silver Spring, Md.)2025n=88B67 influential citations

    Metabolic improvements may precede weight loss. We compared the effects of self-selected 8-h time-restricted eating (TRE), 15% caloric restriction (CR), and unrestricted eating (UE) on weight, body composition, caloric intake, glycemic…

Frequently asked

What dosage was studied?
• Early time-restricted eating plus energy restriction; 8-hour eating window from 7:00 to 15:00 (8-hour eating window daily; weight-loss counseling with energy restriction)
Which population does the evidence apply to?
Most studies investigated: unknown; healthy.
Are there safety considerations for Time-Restricted Eating?
• Not reported in the provided abstract excerpt. • Fatigue was reported more often with iTRE than CR and standard care. • Constipation was reported more often with iTRE and CR than standard care. • Headache was reported more often with iTRE and CR than standard care.

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