Citicoline (CDP-Choline)Studienlage & Dosis

Top-Studien zu Citicoline (CDP-Choline)

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Citicoline in the treatment of acute ischaemic stroke: an international, randomised, multicentre, placebo-controlled study (ICTUS trial).

   Lancet·2012·n=229RCT66 einflussreiche Zitationen

   <h4>Background</h4>Citicoline is approved in some countries for the treatment of acute ischaemic stroke. The drug has shown some evidence of efficacy in a pooled analysis. We sought to confirm the efficacy of citicoline in a larger…

2. 02

   Optic Nerve Neuroprotection in Glaucoma: A Narrative Review.

   Journal of clinical medicine·2024D60 einflussreiche Zitationen

   In recent years, researchers have been interested in neuroprotective therapies as a cutting-edge therapeutic strategy to treat neurodegenerative disorders by shielding the brain system from harmful events. Millions of individuals worldwide…

3. 03

   Effect of citicoline on functional and cognitive status among patients with traumatic brain injury: Citicoline Brain Injury Treatment Trial (COBRIT).

   JAMA·2012·n=121RCT54 einflussreiche Zitationen

   <h4>Context</h4>Traumatic brain injury (TBI) is a serious public health problem in the United States, yet no treatment is currently available to improve outcome after TBI. Approved for use in TBI in 59 countries, citicoline is an…

4. 04

   A randomized dose-response trial of citicoline in acute ischemic stroke patients. Citicoline Stroke Study Group.

   Neurology·1997·n=259RCT52 einflussreiche Zitationen

   Citicoline (CDP-choline) is a key intermediary in the biosynthesis of phosphatidylcholine, an important component of the neural cell membrane. It has been shown to produce beneficial effects in both animal models and non-US clinical stroke…

5. 05

   Effect of citicoline on ischemic lesions as measured by diffusion-weighted magnetic resonance imaging. Citicoline 010 Investigators.

   Ann Neurol·2000·n=100RCT48 einflussreiche Zitationen

   We examined the effect of the neuroprotective and neuroreparative agent citicoline on the growth of cerebral ischemic lesions in a double-blind placebo-controlled study involving patients with acute ischemic stroke using diffusion-weighted…

6. 06

   Comparative efficacy of neuroprotective agents for improving neurological function and prognosis in acute ischemic stroke: a network meta-analysis.

   Front Neurosci·2024·n=12.210Systematic Review47 einflussreiche Zitationen

   <h4>Background</h4>Ischemic stroke is the second leading cause of death and the third leading cause of combined disability and mortality globally. While reperfusion therapies play a critical role in the management of acute ischemic stroke…

7. 07

   A randomized efficacy trial of citicoline in patients with acute ischemic stroke.

   Stroke·1999·n=394RCT46 einflussreiche Zitationen

   <h4>Background and purpose</h4>Citicoline (cytidine-5'-diphosphocholine; CDP-choline) may reduce central nervous system ischemic injury by stabilizing cell membranes and reducing free radical generation. A previous dose-comparison trial in…

8. 08

   Oral citicoline in acute ischemic stroke: an individual patient data pooling analysis of clinical trials.

   Stroke·2002·n=165Meta-Analysis42 einflussreiche Zitationen

   <h4>Background and purpose</h4>No single neuroprotective agent has been shown to influence outcome after acute stroke. Citicoline has been studied worldwide in many clinical trials with positive findings, but only 1 trial has obtained…

9. 09

   Application of Citicoline in Neurological Disorders: A Systematic Review.

   Nutrients·2020·n=47systematic41 einflussreiche Zitationen

   Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely…

10. 10

    Unveiling citicoline's mechanisms and clinical relevance in the treatment of neuroinflammatory disorders.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2024D39 einflussreiche Zitationen

    Citicoline, a compound produced naturally in small amounts in the human body, assumes a pivotal role in phosphatidylcholine synthesis, a dynamic constituent of membranes of neurons. Across diverse models of brain injury and…

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