Acetyl-L-Carnitine (ALCAR)Studienlage & Dosis

Top-Studien zu Acetyl-L-Carnitine (ALCAR)

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder.

   Mol Psychiatry·2021·n=49Meta-Analysis133 einflussreiche Zitationen

   Major depressive disorder (MDD) is a serious mental illness, characterized by high morbidity, which has increased in recent decades. However, the molecular mechanisms underlying MDD remain unclear. Previous studies have identified altered…

   Befund: The meta-analysis identified 23 metabolites that differed significantly between MDD patients and controls across 46 studies.

2. 02

   Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans.

   Am J Clin Nutr·2020·n=15RCT69 einflussreiche Zitationen

   <h4>Background</h4>Nicotinamide riboside (NR) is an NAD+ precursor that boosts cellular NAD+ concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation.<h4>Objectives</h4>We aimed to…

3. 03

   Effect of metabolic and antioxidant supplementation on sperm parameters in oligo-astheno-teratozoospermia, with and without varicocele: A double-blind placebo-controlled study.

   Andrologia·2018·n=104RCT69 einflussreiche Zitationen

   Since sperm require high energy levels to perform their specialised function, it is vital that essential nutrients are available for spermatozoa when they develop, capacitate and acquire motility. However, they are vulnerable to a lack of…

4. 04

   Long-term acetyl-L-carnitine treatment in Alzheimer's disease.

   Neurology·1991·n=130RCT62 einflussreiche Zitationen

   In a double-blind, placebo-controlled, parallel-group, randomized clinical trial, we studied the efficacy of long-term (1-year) oral treatment with acetyl-L-carnitine in 130 patients with a clinical diagnosis of Alzheimer's disease. We…

5. 05

   Double-blind, randomised, placebo-controlled trial on the effect of L-carnitine and L-acetylcarnitine on sperm parameters in men with idiopathic oligoasthenozoospermia.

   Andrologia·2019·n=175RCT62 einflussreiche Zitationen

   Carnitine is essential for energy metabolism and spermatozoa maturation. Combining L-carnitine and L-acetylcarnitine with micronutrients has been investigated as a treatment for infertility in men. We evaluated the effects of a therapeutic…

6. 06

   A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia.

   Fertil Steril·2004·n=60RCT60 einflussreiche Zitationen

   <h4>Objective</h4>To determine the efficacy of combined l-carnitine and l-acetyl-carnitine therapy in infertile males with oligo-astheno-teratozoospermia.<h4>Design</h4>Placebo-controlled double-blind randomized…

7. 07

   Acetyl-l-carnitine deficiency in patients with major depressive disorder.

   Proc Natl Acad Sci U S A·2018Clinical Trial54 einflussreiche Zitationen

   Significance Identifying biological targets in major depressive disorder (MDD) is a critical step for development of effective mechanism-based medications. The epigenetic agent acetyl- l -carnitine (LAC) has rapid and enduring…

8. 08

   Randomized double-blind placebo-controlled trial of acetyl-L-carnitine for the prevention of taxane-induced neuropathy in women undergoing adjuvant breast cancer therapy.

   J Clin Oncol·2013·n=409RCT52 einflussreiche Zitationen

   <h4>Purpose</h4>Chemotherapy-induced peripheral neuropathy (CIPN) is common and leads to suboptimal treatment. Acetyl-L-carnitine (ALC) is a natural compound involved in neuronal protection. Studies have suggested ALC may be effective for…

9. 09

   Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy: an analysis of two randomized placebo-controlled trials.

   Diabetes Care·2005·n=125RCT50 einflussreiche Zitationen

   <h4>Objective</h4>We evaluated frozen databases from two 52-week randomized placebo-controlled clinical diabetic neuropathy trials testing two doses of acetyl-L-carnitine (ALC): 500 and 1,000 mg/day t.i.d.<h4>Research design and…

10. 10

    Neuropsychiatric Manifestations of COVID-19 Disease and Post COVID Syndrome: The Role of N-acetylcysteine and Acetyl-L-carnitine.

    Curr Neuropharmacol·2025·n=19review50 einflussreiche Zitationen

    COVID-19 is associated with neuropsychiatric symptoms, such as anosmia, anxiety, depression, stress-related reactions, and psychoses. The illness can cause persistent cognitive impairment and "brain fog", suggesting chronic brain…

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