Kognition

Blut-Hirn-SchrankeStudienlage & Dosis

Selektive Durchlässigkeit, Substanzdurchtritt, Entzündungs-Permeabilität.

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 43
Meta / Systematic / RCT: 1
Häufig zitiert: 10
Erscheinungsjahre: 1955–2026

Blut-Hirn-Schranke im Kontext von Kognition

Dieses Thema ist Teil unserer Welt „Kognition". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Kognition

Top-Studien zu Blut-Hirn-Schranke

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Blood-brain barrier breakdown in the aging human hippocampus.
Neuron2015n=2.011200 einflussreiche Zitationen
The blood-brain barrier (BBB) limits entry of blood-derived products, pathogens, and cells into the brain that is essential for normal neuronal functioning and information processing. Post-mortem tissue analysis indicates BBB damage in…
Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice.
The Journal of cell biology2003n=12200 einflussreiche Zitationen
Tight junctions are well-developed between adjacent endothelial cells of blood vessels in the central nervous system, and play a central role in establishing the blood-brain barrier (BBB). Claudin-5 is a major cell adhesion molecule of…
RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain.
Nature medicine2003200 einflussreiche Zitationen
Amyloid-beta peptide (Abeta) interacts with the vasculature to influence Abeta levels in the brain and cerebral blood flow, providing a means of amplifying the Abeta-induced cellular stress underlying neuronal dysfunction and dementia.…
Transport of brain-derived neurotrophic factor across the blood-brain barrier.
Neuropharmacology1998200 einflussreiche Zitationen
Brain-derived neurotrophic factor (BDNF) is a potential therapeutic agent for degenerative disorders of the central nervous system. In this report, we investigated the ability of BDNF to cross the blood-brain barrier (BBB). BDNF was stable…
High throughput artificial membrane permeability assay for blood-brain barrier.
European journal of medicinal chemistry2003200 einflussreiche Zitationen
The recent advances in high throughput screening for biological activities and combinatorial chemistry have greatly expanded the number of drug candidates. Rapid screening for BBB penetration potential early in drug discovery programs…
Exosome delivered anticancer drugs across the blood-brain barrier for brain cancer therapy in Danio rerio.
Pharmaceutical research2015n=20200 einflussreiche Zitationen
<h4>Purpose</h4>The blood-brain barrier (BBB) essentially restricts therapeutic drugs from entering into the brain. This study tests the hypothesis that brain endothelial cell derived exosomes can deliver anticancer drug across the BBB for…
Flavonoid permeability across an in situ model of the blood-brain barrier.
Free radical biology & medicine2004128 einflussreiche Zitationen
Understanding mechanisms associated with flavonoid neuroprotection is complicated by the lack of information on their ability to enter the CNS. This study examined naringenin and quercetin permeability across the blood-brain barrier (BBB),…
Interaction between flavonoids and the blood-brain barrier: in vitro studies.
Journal of neurochemistry2003122 einflussreiche Zitationen
There is considerable current interest in the neuroprotective effects of flavonoids. This study focuses on the potential for dietary flavonoids, and their known physiologically relevant metabolites, to enter the brain endothelium and cross…
Selective expression of the large neutral amino acid transporter at the blood-brain barrier.
Proceedings of the National Academy of Sciences of the United States of America199992 einflussreiche Zitationen
Amino acid supply in brain is regulated by the activity of the large neutral amino acid transporter (LAT) at the brain capillary endothelial cell, which forms the blood-brain barrier (BBB) in vivo. Bovine BBB poly(A)(+) RNA was isolated…
Blood-Brain Barrier Disruption in Schizophrenia: Insights, Mechanisms, and Future Directions.
Int J Mol Sci2025n=13Review77 einflussreiche Zitationen
The blood-brain barrier (BBB) plays a crucial role in maintaining the homeostasis of the central nervous system by regulating solute transport and preventing neurotoxic substances from infiltrating brain tissue. In schizophrenia, emerging…