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Longevity

SpermidinStudienlage & Dosis

Autophagie-Induktor, Weizenkeime, Lebensspannen-Daten in Tier und Mensch.

Studienlage in Zahlen

Studien gesamt
61
Mit Abstract
48
Meta / Systematic / RCT
4
Häufig zitiert
14
Erscheinungsjahre
2009–2026

Spermidin im Kontext von Longevity

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Zur Welt Longevity

Top-Studien zu Spermidin

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Spermidine is essential for fasting-mediated autophagy and longevity.

    Nat Cell Biol2024n=104other174 einflussreiche Zitationen

    Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model organisms and improve human health. The natural polyamine spermidine has been similarly linked to autophagy enhancement, geroprotection and reduced…

  2. Spermidine Ameliorates Colitis via Induction of Anti-Inflammatory Macrophages and Prevention of Intestinal Dysbiosis.

    Journal of Crohn's & colitis2023n=3274 einflussreiche Zitationen

    Background and Aims Exacerbated immune activation, intestinal dysbiosis and a disrupted intestinal barrier are common features among inflammatory bowel disease [IBD] patients. The polyamine spermidine, which is naturally present in all…

  3. Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial.

    JAMA Netw Open2022n=100RCT65 einflussreiche Zitationen

    <h4>Importance</h4>Developing interventions against age-related memory decline and for older adults experiencing neurodegenerative disease is one of the greatest challenges of our generation. Spermidine supplementation has shown beneficial…

  4. Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways.

    International immunopharmacology202355 einflussreiche Zitationen

    <h4>Background</h4>Aryl hydrocarbon receptor (AhR) activation promotes intestinal barrier repair and enhances the gut mucosal barrier function in inflammatory bowel diseases (IBD). Spermidine is beneficial in several murine models of IBD…

  5. The effect of spermidine on memory performance in older adults at risk for dementia: A randomized controlled trial.

    Cortex2018n=30RCT49 einflussreiche Zitationen

    INTRODUCTION: Nutritional intervention with the natural polyamine spermidine, an autophagy-enhancing agent, can prevent memory loss in aging model organisms. This is the first human study to evaluate the impact of spermidine…

  6. Spermidine from arginine metabolism activates Nrf2 and inhibits kidney fibrosis.

    Communications biology2023n=1046 einflussreiche Zitationen

    Kidney metabolism may be greatly altered in chronic kidney disease. Here we report that arginine metabolism is the most altered in unilateral ureteral obstruction (UUO)-induced fibrosis of the kidneys in metabolomic analysis. Spermidine is…

  7. Tumor cell-derived spermidine is an oncometabolite that suppresses TCR clustering for intratumoral CD8 + T cell activation.

    Proceedings of the National Academy of Sciences of the United States of America2023n=841 einflussreiche Zitationen

    The activation and expansion of T cells that recognize cancer cells is an essential aspect to antitumor immunity. Tumors may escape destruction by the immune system through ectopic expression of inhibitory immune ligands typically…

  8. High-Dose Spermidine Supplementation Does Not Increase Spermidine Levels in Blood Plasma and Saliva of Healthy Adults: A Randomized Placebo-Controlled Pharmacokinetic and Metabolomic Study.

    Nutrients2023n=12RCT37 einflussreiche Zitationen

    (1) Background: Spermidine is a biogenic polyamine that plays a crucial role in mammalian metabolism. As spermidine levels decline with age, spermidine supplementation is suggested to prevent or delay age-related diseases. However, valid…

  9. Spermidine as a promising anticancer agent: Recent advances and newer insights on its molecular mechanisms.

    Frontiers in chemistry202332 einflussreiche Zitationen

    Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically…

  10. Spermidine promotes retinal ganglion cell survival and optic nerve regeneration in adult mice following optic nerve injury.

    Cell death &amp; disease201530 einflussreiche Zitationen

    Spermidine acts as an endogenous free radical scavenger and inhibits the action of reactive oxygen species. In this study, we examined the effects of spermidine on retinal ganglion cell (RGC) death in a mouse model of optic nerve injury…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Fasting/intermittent fasting, caloric restriction, spermidine supplementation, DFMO, ODC1/SPE1 inhibition or knockdown, rapamycin, GC7 (Human fasting ~250 kcal/day for 7–13 days; flies 10 mM DFMO; mice 0.25% or 0.5% DFMO; 3 mM SPD in water; yeast 100 µM or 5 mM SPD; GC7 50 mM stock, used pharmacologically; rapamycin 40 nM) • Spermidine-rich dietary supplement extracted from wheat germ (0.9 mg spermidine/d; 750 mg plant extract daily (6 capsules of 125 mg each))
Für welche Population gilt die Evidenz?
Die meisten Studien untersuchten: unknown.
Gibt es Sicherheitshinweise zu Spermidin?
• DFMO blunted IF benefits in flies and mice, indicating a dose/target ceiling for polyamine suppression. • In flies, DFMO generally seemed non-toxic and did not affect food consumption or acute body weight. • No major adverse events were reported for human fasting cohorts in the excerpt. • All 19 serious adverse events were judged unrelated to treatment.

Weitere Themen in Longevity

Zone 2

Niedrig-intensives Cardio — mitochondriale Biogenese, Longevity-Basis.

Rapamycin

mTOR-Inhibition, Langlebigkeits-Studien, Off-Label-Dosierung und Sicherheit.

AMPK Activators

Berberin, Alpha-Liponsäure, energetic stress und Glukose-Modulation.

ApoB

Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.

Autophagie

Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.

Berberin

Glukose, Lipide, AMPK und GI-Verträglichkeits-Daten.

Biologisches Alter

GrimAge, PhenoAge, DunedinPACE — was Epigenetik-Uhren messen.

Caloric Restriction

CR-Mimetika, Lebensspannen-Forschung und NHP-Studien.

Krebsfrüherkennung

Empfehlungen, Über-Diagnose, Galleri-Tests, Ganzkörper-MRT (kritisch).

Zelluläre Seneszenz

„Zombie-Zellen", SASP, Senolytika-Ansätze.

Kollagen

Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.

Demenz-Prävention

Lifestyle-Faktoren: Bewegung, Schlaf, Hörgesundheit, Vaskuläre Gesundheit.

DEXA-Knochendichte

DEXA-Scan für Knochen + Körperzusammensetzung — Verlauf wichtiger als Einzelwert.

Epigenetische Uhren

Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.

Epigenetik

DNA-Methylierung, Histon-Modifikationen, Umwelteinflüsse auf Genexpression.

Exosomen

Zell-Kommunikation, regenerative Anwendungen, frühes Forschungsfeld.

Genetiktests

Variants, Pharmacogenomik, Limitationen — Methylierung, MTHFR-Mythen.

Glucosamine

Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.

Glycin

Methylierung, Kollagensynthese, Lebensspannen-Hinweise in Tiermodellen.

Griffkraft

Starker Mortalitäts-Prädiktor — einfach messbar, trainierbar.

Verwandte Themen aus anderen Welten

Schlaf

Schlafzyklen

90-Minuten-Zyklen — Tiefschlaf vorne, REM hinten in der Nacht.

Schlaf

Sleep Tracking

Wearables (Oura, Whoop) und HRV-Sleep-Korrelationen.

Vitamine & Mineralien

Herz-Kreislauf-System

Blutdruck, Herzfrequenz, Endothel, Cholesterin, kardiovaskuläre Risikofaktoren.

Vitamine & Mineralien

Effektstärke

p-Wert vs. praktische Relevanz, Cohen's d, Confidence Intervals.

Vitamine & Mineralien

Melatonin-Optimierung

Melatonin-Bedarf, Dosierung (0,3–5 mg), retardierte Formen, Circadian-Rhythmus und Sicherheit bei Langzeitanwendung.

Vitamine & Mineralien

Omega-3-Fettsäuren

EPA, DHA, ALA — Bedarf, Quellen (Fisch, Algen), Omega-3-Index als Biomarker und kardiovaskuläre RCT-Daten.