Omega-3-FettsäurenStudienlage & Dosis

Top-Studien zu Omega-3-Fettsäuren

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease.

   Arch Intern Med·2009Systematic Review200 einflussreiche Zitationen

   <h4>Background</h4>Although a wealth of literature links dietary factors and coronary heart disease (CHD), the strength of the evidence supporting valid associations has not been evaluated systematically in a single…

2. 02

   Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals.

   JAMA Cardiol·2018·n=77.917Meta-Analysis200 einflussreiche Zitationen

   <h4>Importance</h4>Current guidelines advocate the use of marine-derived omega-3 fatty acids supplements for the prevention of coronary heart disease and major vascular events in people with prior coronary heart disease, but large trials…

   Befund: Randomization to omega-3 fatty acid supplementation had no significant association with coronary heart disease death in this meta-analysis.

3. 03

   Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

   Cochrane Database Syst Rev·2020·n=162.796meta169 einflussreiche Zitationen

   BACKGROUND: Omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3)), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid (ALA)) may benefit…

   Befund: Increasing ALA intake probably makes little or no difference to all-cause mortality.

4. 04

   Does omega-3 PUFAs supplementation improve metabolic syndrome and related cardiovascular diseases? A systematic review and meta-analysis of randomized controlled trials.

   Crit Rev Food Sci Nutr·2024·n=8.489Meta-Analysis167 einflussreiche Zitationen

   Literature is inconsistent regarding the effects of omega-3 polyunsaturated fatty acids (omega-3 PUFAs) supplementation on patients with metabolic syndrome (MetS) and related cardiovascular diseases (CVDs). Therefore, the aim of this…

5. 05

   Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.

   J Am Heart Assoc·2019·n=127.477meta138 einflussreiche Zitationen

   Background Whether marine omega-3 supplementation is associated with reduction in risk of cardiovascular disease (CVD) remains controversial. Methods and Results This meta-analysis included study-level data from 13 trials. The outcomes of…

   Befund: Marine omega-3 supplementation was associated with a significantly lower risk of myocardial infarction in the analysis excluding REDUCE-IT.

6. 06

   Biomarkers of Dietary Omega-6 Fatty Acids and Incident Cardiovascular Disease and Mortality.

   Circulation·2019·n=68.659Meta-Analysis132 einflussreiche Zitationen

   Background: Global dietary recommendations for and cardiovascular effects of linoleic acid, the major dietary omega-6 fatty acid, and its major metabolite, arachidonic acid, remain controversial. To address this uncertainty and inform…

   Befund: Higher linoleic acid levels were associated with lower risk of total cardiovascular disease in this pooled analysis.

7. 07

   A systemic review of the roles of n-3 fatty acids in health and disease.

   J Am Diet Assoc·2009Systematic Review125 einflussreiche Zitationen

   Attention to the role of n-3 long-chain fatty acids in human health and disease has been continuously increased during recent decades. Many clinical and epidemiologic studies have shown positive roles for n-3 fatty acids in infant…

8. 08

   Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease.

   Cochrane Database Syst Rev·2018·n=112.059meta118 einflussreiche Zitationen

   BACKGROUND: Researchers have suggested that omega-3 polyunsaturated fatty acids from oily fish (long-chain omega-3 (LCn3), including eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)), as well as from plants (alpha-linolenic acid…

   Befund: Increasing LCn3 probably makes little or no difference to all-cause mortality.

9. 09

   Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials.

   Circulation·2019·n=24Meta-Analysis105 einflussreiche Zitationen

   Background: Randomized trials of therapies that primarily lowered triglycerides have not consistently shown reductions in cardiovascular events. Methods: We performed a systematic review and trial-level meta-regression analysis of 3…

   Befund: When REDUCE-IT was removed, the triglyceride association was attenuated and was no longer statistically significant.

10. 10

    Meta-analysis of the effects of eicosapentaenoic acid (EPA) in clinical trials in depression.

    J Clin Psychiatry·2011·n=916Meta-Analysis102 einflussreiche Zitationen

    <h4>Objective</h4>Randomized trials of omega-3 polyunsaturated fatty acid (PUFA) treatment for depression have differed in outcome. Recent meta-analyses ascribe discrepancies to differential effects of eicosapentaenoic acid (EPA) versus…

    Befund: The meta-analysis found that EPA proportion of at least 60% was a significant determinant of superiority of PUFA over placebo.

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