Senolytics (Fisetin)Studienlage & Dosis

Top-Studien zu Senolytics (Fisetin)

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Senolytic drugs: from discovery to translation.

   J Intern Med·2020review200 einflussreiche Zitationen

   Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal…

2. 02

   Cellular Senescence: A Translational Perspective.

   EBioMedicine·2017review200 einflussreiche Zitationen

   Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). Senescent cells…

3. 03

   Fisetin is a senotherapeutic that extends health and lifespan.

   EBioMedicine·2018Study200 einflussreiche Zitationen

   <h4>Background</h4>Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using…

4. 04

   New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463.

   Aging (Albany NY)·2017Study200 einflussreiche Zitationen

   Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of senescent cells by temporarily disabling the pro-survival pathways that enable…

5. 05

   Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.

   Aging Cell·2024other141 einflussreiche Zitationen

   Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related arterial dysfunction, in part, by promoting oxidative stress and inflammation, which reduce the bioavailability of the vasodilatory…

6. 06

   Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases.

   Mech Ageing Dev·2024review110 einflussreiche Zitationen

   Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic agent for the treatment of age-related chronic diseases. Senotherapeutics target…

7. 07

   Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies.

   Cancers (Basel)·2020Review91 einflussreiche Zitationen

   Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour…

8. 08

   Senolytic intervention improves cognition, metabolism, and adiposity in female APP(NL)(-F/NL-F) mice.

   Geroscience·2025Study90 einflussreiche Zitationen

   Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer's disease (AD). The APP^NL-F/NL-F amyloidogenic AD mouse model exhibits increased markers of senescent cells and the…

9. 09

   Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.

   Frontiers in immunology·2018·n=72D81 einflussreiche Zitationen

   Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases,…

10. 10

    IL-23R is a senescence-linked circulating and tissue biomarker of aging.

    Nat Aging·2025other75 einflussreiche Zitationen

    Cellular senescence is an aging mechanism characterized by cell cycle arrest and a senescence-associated secretory phenotype (SASP). Preclinical studies demonstrate that senolytic drugs, which target survival pathways in senescent cells,…

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