Back to Longevity
Longevity

Senolytics (Fisetin)Evidence & Dosage

Cellular senescence, Fisetin protocols, and senolytic studies.

Studies last updated

Evidence at a glance

Total studies
657
With abstract
49
Meta / Systematic / RCT
13
Highly cited
50
Publication years
2003–2026

Senolytics (Fisetin) in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

Go to Longevity

Top studies on Senolytics (Fisetin)

Ranked by influential-citation count and publication year.

  1. Senolytic drugs: from discovery to translation.

    J Intern Med2020review200 influential citations

    Senolytics are a class of drugs that selectively clear senescent cells (SC). The first senolytic drugs Dasatinib, Quercetin, Fisetin and Navitoclax were discovered using a hypothesis-driven approach. SC accumulate with ageing and at causal…

  2. Cellular Senescence: A Translational Perspective.

    EBioMedicine2017review200 influential citations

    Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). Senescent cells…

  3. Fisetin is a senotherapeutic that extends health and lifespan.

    EBioMedicine2018Study200 influential citations

    <h4>Background</h4>Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using…

  4. New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463.

    Aging (Albany NY)2017Study200 influential citations

    Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of senescent cells by temporarily disabling the pro-survival pathways that enable…

  5. Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence.

    Aging Cell2024other141 influential citations

    Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related arterial dysfunction, in part, by promoting oxidative stress and inflammation, which reduce the bioavailability of the vasodilatory…

  6. Fisetin as a senotherapeutic agent: Evidence and perspectives for age-related diseases.

    Mech Ageing Dev2024review110 influential citations

    Fisetin, a flavonoid naturally occurring in plants, fruits, and vegetables, has recently gained attention for its potential role as a senotherapeutic agent for the treatment of age-related chronic diseases. Senotherapeutics target…

  7. Senescence and Cancer: A Review of Clinical Implications of Senescence and Senotherapies.

    Cancers (Basel)2020Review91 influential citations

    Cellular senescence is a key component of human aging that can be induced by a range of stimuli, including DNA damage, cellular stress, telomere shortening, and the activation of oncogenes. Senescence is generally regarded as a tumour…

  8. Senolytic intervention improves cognition, metabolism, and adiposity in female APP(NL)(-F/NL-F) mice.

    Geroscience2025Study90 influential citations

    Senescent cells accumulate throughout the body and brain contributing to unhealthy aging and Alzheimer's disease (AD). The APP<sup>NL-F/NL-F</sup> amyloidogenic AD mouse model exhibits increased markers of senescent cells and the…

  9. Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases.

    Frontiers in immunology2018n=72D81 influential citations

    Increasing evidence from diverse sources during the past several years has indicated that long-term, low level, chronic inflammation mediates several chronic diseases including cancer, arthritis, obesity, diabetes, cardiovascular diseases,…

  10. IL-23R is a senescence-linked circulating and tissue biomarker of aging.

    Nat Aging2025other75 influential citations

    Cellular senescence is an aging mechanism characterized by cell cycle arrest and a senescence-associated secretory phenotype (SASP). Preclinical studies demonstrate that senolytic drugs, which target survival pathways in senescent cells,…

Frequently asked

What dosage was studied?
• Senolytic agents / targeting senescent cell anti-apoptotic pathways (not reported)
Are there safety considerations for Senolytics (Fisetin)?
• Not reported • Not reported in the abstract.

More topics in Longevity

Zone 2 Training

Low-intensity cardio — mitochondrial biogenesis, a longevity foundation.

Rapamycin

mTOR inhibition, longevity studies, off‑label dosing, and safety.

AMPK Activators

Berberine, alpha‑lipoic acid, energetic stress, and glucose modulation.

ApoB

A better cardiovascular risk metric than LDL-C — modern lipidology.

Autophagy

Cellular self-clearance — fasting, exercise, spermidine as triggers.

Berberin

Glucose, lipids, AMPK and GI tolerability data

Biological Age

GrimAge, PhenoAge, DunedinPACE — what epigenetic clocks measure.

Caloric Restriction

CR mimetics, lifespan research, and NHP studies.

Cancer Screening

Recommendations, overdiagnosis, Galleri tests, whole-body MRI (a critical look).

Cellular Senescence

"Zombie cells," SASP, senolytic approaches.

Collagen

Skin, joints, tendons — evidence favors hydrolysate plus vitamin C.

Dementia Prevention

Lifestyle factors: exercise, sleep, hearing health, vascular health.

DEXA Bone Density

DEXA scan for bone + body composition — the trend matters more than a single value.

Epigenetic Clocks

Horvath, GrimAge, PhenoAge — what they measure and what they don't.

Epigenetics

DNA methylation, histone modifications, environmental influences on gene expression.

Exosomes

Cell-to-cell communication, regenerative applications, an early research field.

Genetic Tests

Variants, pharmacogenomics, limitations — methylation, MTHFR myths.

Glucosamine

Joints, UK Biobank mortality study, sulfate vs HCl forms.

Glycine

Methylation, collagen synthesis, lifespan signals in animal models.

Grip Strength

A strong mortality predictor — easy to measure, trainable.

Related topics from other worlds

Peptides

Purity & Research Chemicals

Lab testing, source vetting, contamination risks on the gray market.

Peptides

Tesamorelin

Approved for HIV-associated lipodystrophy — visceral fat reduction.

Performance

ATP System

Phosphagen system, anaerobic glycolysis, oxidative phosphorylation.

Performance

Deload

Planned recovery periods — avoiding overreaching.

Performance

HMB

Sarcopenia, Anti-Catabolic, and Sports Applications

Performance

Nitrate

Nitric oxide precursor, endurance performance, blood pressure lowering.