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ProlactinEvidence & Dosage

Stress/sleep hormone, suppresses testosterone when chronically elevated.

Evidence at a glance

Total studies
444
With abstract
48
Meta / Systematic / RCT
0
Highly cited
24
Publication years
1952–2026

Prolactin in the context of Hormones

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Top studies on Prolactin

Ranked by influential-citation count and publication year.

  1. Prolactin: structure, function, and regulation of secretion.

    Physiological reviews2000200 influential citations

    Prolactin is a protein hormone of the anterior pituitary gland that was originally named for its ability to promote lactation in response to the suckling stimulus of hungry young mammals. We now know that prolactin is not as simple as…

  2. The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy.

    Endocrinology1975200 influential citations

    The hormonal factors associated with converting a corpus luteum of estrous cycle into a corpus luteum of pseudopregnancy were studied by measuring LH and FSH prolactin, estradiol and progesterone levels in decapitated rats during the 4-day…

  3. Prolactin - a pleiotropic factor in health and disease.

    Nature reviews. Endocrinology2019108 influential citations

    The principal role of prolactin in mammals is the regulation of lactation. Prolactin is a hormone that is mainly synthesized and secreted by lactotroph cells in the anterior pituitary gland. Prolactin signalling occurs via a unique…

  4. Prolactin-secreting adenomas: pathogenesis, diagnosis, and management

    The Lancet Diabetes & Endocrinology202576 influential citations

    Hyperprolactinaemia can result from physiological causes, pharmacological agents, or pathological conditions such as prolactin-secreting pituitary adenomas and other pituitary stalk-compressing masses. Sporadic prolactinomas are the most…

  5. A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.

    Cell200763 influential citations

    Postpartum cardiomyopathy (PPCM) is a disease of unknown etiology and exposes women to high risk of mortality after delivery. Here, we show that female mice with a cardiomyocyte-specific deletion of stat3 develop PPCM. In these mice,…

  6. Dopamine as a prolactin (PRL) inhibitor.

    Endocrine reviews200152 influential citations

    Dopamine is a small and relatively simple molecule that fulfills diverse functions. Within the brain, it acts as a classical neurotransmitter whose attenuation or overactivity can result in disorders such as Parkinson's disease and…

  7. What can we learn from rodents about prolactin in humans?

    Endocrine reviews200841 influential citations

    Prolactin (PRL) is a 23-kDa protein hormone that binds to a single-span membrane receptor, a member of the cytokine receptor superfamily, and exerts its action via several interacting signaling pathways. PRL is a multifunctional hormone…

  8. Antipsychotic-Related Prolactin Changes: A Systematic Review and Dose–Response Meta-analysis

    CNS Drugs202539 influential citations

    <h4>Background</h4>Prolactin increase is a common and potentially problematic adverse event of antipsychotics. We aimed to discover the relationship between antipsychotic doses and changes in prolactin levels.<h4>Objective</h4>To examine…

  9. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response.

    EMBO Journal199429 influential citations

    Milk protein gene expression in mammary epithelial cells is regulated by the action of the lactogenic hormones insulin, glucocorticoids and prolactin. The mammary gland factor, MGF, has been shown to be a central mediator in the lactogenic…

  10. Conditional Deletion of the Prolactin Receptor Reveals Functional Subpopulations of Dopamine Neurons in the Arcuate Nucleus of the Hypothalamus.

    The Journal of neuroscience : the official journal of the Society for Neuroscience201629 influential citations

    <h4>Unlabelled</h4>Tuberoinfundibular dopamine (TIDA) neurons, known as neuroendocrine regulators of prolactin secretion from the pituitary gland, also release GABA within the hypothalamic arcuate nucleus. As these neurons express…

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