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Longevity

InflammagingEvidence & Dosage

Chronic low-grade inflammation with aging — drivers and countermeasures.

Evidence at a glance

Total studies
971
With abstract
49
Meta / Systematic / RCT
0
Highly cited
12
Publication years
1993–2026

Inflammaging in the context of Longevity

This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Inflammaging

Ranked by influential-citation count and publication year.

  1. Nonuniversality of inflammaging across human populations.

    Nature aging2025145 influential citations

    Inflammaging, an age-associated increase in chronic inflammation, is considered a hallmark of aging. However, there is no consensus approach to measuring inflammaging based on circulating cytokines. Here we assessed whether an inflammaging…

  2. Inflammaging as a target for healthy ageing.

    Age Ageing2023review120 influential citations

    Life expectancy has been on the rise for the past few decades, but healthy life expectancy has not kept pace, leading to a global burden of age-associated disorders. Advancing age is accompanied by a chronic increase in basal systemic…

  3. Age-related bone diseases: Role of inflammaging.

    Journal of autoimmunity2024108 influential citations

    Bone aging is characterized by an imbalance in the physiological and pathological processes of osteogenesis, osteoclastogenesis, adipogenesis, and chondrogenesis, resulting in exacerbated bone loss and the development of age-related bone…

  4. The 3 I's of immunity and aging: immunosenescence, inflammaging, and immune resilience.

    Front Aging2024review100 influential citations

    As we age, our immune system's ability to effectively respond to pathogens declines, a phenomenon known as immunosenescence. This age-related deterioration affects both innate and adaptive immunity, compromising immune function and leading…

  5. Inflammaging and Brain Aging.

    International journal of molecular sciences202498 influential citations

    Progress made by the medical community in increasing lifespans comes with the costs of increasing the incidence and prevalence of age-related diseases, neurodegenerative ones included. Aging is associated with a series of morphological…

  6. Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches.

    Aging and disease202444 influential citations

    Inflammaging refers to chronic, low-grade inflammation that becomes more common with age and plays a central role in the pathophysiology of various vascular diseases. Key inflammatory mediators involved in inflammaging contribute to…

  7. Cardiovascular inflammaging: Mechanisms, consequences, and therapeutic perspectives.

    Cell reports. Medicine2025D40 influential citations

    Both aging and systemic inflammation are major risk factors for cardiovascular disease. This review summarizes the interrelationship of aging and inflammation-known as inflammaging-and the consequences for cardiovascular health. We discuss…

  8. Autophagy Controls Acquisition of Aging Features in Macrophages.

    Journal of innate immunity201539 influential citations

    Macrophages provide a bridge linking innate and adaptive immunity. An increased frequency of macrophages and other myeloid cells paired with excessive cytokine production is commonly seen in the aging immune system, known as…

  9. Exploring the complex relations between inflammation and aging (inflamm-aging): anti-inflamm-aging remodelling of inflamm- aging, from robustness to frailty.

    Inflammation research : official journal of the European Histamine Research Society ... [et al.]2008E24 influential citations

    "Inflamm-aging" denotes the up-regulation of certain pro-inflammatory cytokines at older ages, and associated chronic diseases. It is well known that blood levels of cortisol also increase with age, an increase commonly considered to be…

  10. Immunosenescence and inflammaging: Mechanisms and modulation through diet and lifestyle.

    Frontiers in immunology2025D23 influential citations

    Aging is associated with profound alterations in the immune system, characterized by immunosenescence and inflammaging, which together compromise host defense, promote chronic low-grade inflammation, and contribute to the development of…

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