Receptor SensitivityEvidence & Dosage
Up-/downregulation, tolerance, hormone resistance as a phenomenon.
Evidence at a glance
- Total studies
- 126
- With abstract
- 35
- Meta / Systematic / RCT
- 0
- Highly cited
- 1
- Publication years
- 1978–2026
Receptor Sensitivity in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on Receptor Sensitivity
Ranked by influential-citation count and publication year.
Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer.
Journal of the National Cancer Institute2005n=10293 influential citations<h4>Background</h4>Gefitinib is a selective inhibitor of the epidermal growth factor (EGFR) tyrosine kinase, which is overexpressed in many cancers, including non-small-cell lung cancer (NSCLC). We carried out a clinical study to compare…
A Five-Plasma Protein-Based Algorithm for Predicting Incident CKD in Type 2 Diabetes.
Journal of the American Society of Nephrology : JASN2026n=1,5802 influential citations<h4>Key points</h4>Proteomics analyses consistently identified nine independent protein predictors for CKD in both Chinese and European participants with type 2 diabetes. A novel prediction model, "eGFR+five-protein panel predicting CKD,"…
The NOTCH3 extracellular domain is a serum biomarker for pulmonary arterial hypertension.
Nature medicine2026n=3411 influential citationsNew biomarkers are needed to detect and follow individuals with World Health Organization group 1.1 pulmonary hypertension (idiopathic pulmonary arterial hypertension (IPAH)). As NOTCH3 cleavage occurs constitutively in the lungs of…
Glucocorticoid-Induced Tumor Necrosis Factor Receptor Ligand: Correlation and Therapeutic Potential for Cognitive Impairment in Temporal Lobe Epilepsy.
Clinical and translational science2026n=211 influential citationsImmune checkpoint regulators can improve neurological functions in Alzheimer's disease. However, it remains blurred whether these regulators may ameliorate temporal lobe epilepsy (TLE) and TLE-related cognitive impairment. This study…
Improving a Plasma Biomarker Panel for Early Detection of Pancreatic Ductal Adenocarcinoma with Aminopeptidase N (ANPEP) and Polymeric Immunoglobulin Receptor (PIGR).
Clinical cancer research : an official journal of the American Association for Cancer Research2026n=5371 influential citations<h4>Purpose</h4>Pancreatic ductal adenocarcinoma (PDAC) is typically detected too late for useful therapeutic interventions; hence, we sought blood biomarkers to detect early-stage disease.<h4>Experimental design</h4>Using mass…
Biotin-specific molecularly imprinted polymers as a biomimetic test line in lateral flow assays.
Biosensors & bioelectronics20261 influential citationsLateral flow assays are widely used for rapid diagnostics at the point of care. However, their dependence on biological receptors limits their stability, scalability, and cost-effectiveness. This work demonstrates the use of…
Prognostic performance of thymidine kinase 1 activity in patients with hormone receptor-positive and HER2-negative metastatic breast cancer treated with CDK4/6 and aromatase inhibitors.
Breast cancer research and treatment2026n=901 influential citations<h4>Purpose</h4>Thymidine kinase 1 activity (TKa) has previously been demonstrated as a prognostic biomarker for progression-free survival (PFS) in hormone receptor-positive, HER2-negative metastatic breast cancer (MBC), but its optimal…
Diabetes in pregnancy attenuates the sFlt-1/PlGF ratio for prediction of preeclampsia.
Pregnancy hypertension2026n=9651 influential citations<h4>Objectives</h4>This study investigate the angiogenic imbalance of soluble fms-like tyrosine kinase 1 (sFlt-1) and placental growth factor (PlGF) among women with any diabetes in pregnancy and suspected preeclampsia.<h4>Study…
Deep learning on histopathological images to predict breast cancer recurrence risk and chemotherapy benefit: a multicentre, model development and validation study.
The Lancet. Oncology2026n=8,2841 influential citations<h4>Background</h4>Genomic assays such as Oncotype DX have transformed adjuvant treatment selection for hormone receptor-positive, HER2-negative, early breast cancer but remain inaccessible to many patients because of high cost and…
Chopped optical biosensing enables temporal background subtraction for high-sensitivity fluorescence immunoassays
Talanta2026Fluorescence-based immunoassays are widely used for sensitive biomarker detection, but their performance at low analyte concentrations is often limited by background signals originating from unbound fluorophores, Raman scattering, and…
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