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Hormones

PCOSEvidence & Dosage

Polycystic ovary syndrome — insulin resistance, androgens, lifestyle.

Evidence at a glance

Total studies
1,000
With abstract
49
Meta / Systematic / RCT
11
Highly cited
17
Publication years
1990–2026

PCOS in the context of Hormones

This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on PCOS

Ranked by influential-citation count and publication year.

  1. Controversy in clinical endocrinology: diagnosis of polycystic ovarian syndrome: the Rotterdam criteria are premature.

    The Journal of clinical endocrinology and metabolism200695 influential citations

    <h4>Context</h4>Polycystic ovary syndrome (PCOS) is defined most commonly according to the proceedings of an expert conference sponsored by the National Institutes of Health (NIH) in April 1990, which noted the disorder as having 1)…

  2. Definitions, prevalence and symptoms of polycystic ovaries and polycystic ovary syndrome.

    Best practice &amp; research. Clinical obstetrics &amp; gynaecology200468 influential citations

    Polycystic ovarian morphology is seen on ultrasound in approximately 22% of women. Polycystic ovary syndrome (PCOS) is a common and perplexing endocrine disorder of women in their reproductive years, with a prevalence of up to 10%.…

  3. Functional genomics of PCOS: from GWAS to molecular mechanisms.

    Trends in endocrinology and metabolism: TEM201562 influential citations

    Polycystic ovary syndrome (PCOS) is a common endocrinopathy characterized by increased ovarian androgen biosynthesis, anovulation, and infertility. PCOS has a strong heritable component based on familial clustering and twin studies.…

  4. Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.

    The Cochrane database of systematic reviews2003n=54356 influential citations

    <h4>Background</h4>Polycystic ovary syndrome (PCOS) is characterised by anovulation, hyperandrogenaemia and insulin resistance. Hyperinsulinaemia is known to be associated with an increase in cardiovascular risk and the development of…

  5. Effects of Curcumin on Glycemic Control and Lipid Profile in Polycystic Ovary Syndrome: Systematic Review with Meta-Analysis and Trial Sequential Analysis.

    Nutrients2021n=3Meta-Analysis53 influential citations

    The therapeutic effects of curcumin for polycystic ovary syndrome (PCOS) remain inconclusive. The present study aims to evaluate the effects of curcumin on glycemic control and lipid profile in patients with PCOS. PubMed, Embase, Scopus,…

  6. Stockpiling of transitional and classic primary follicles in ovaries of women with polycystic ovary syndrome.

    The Journal of clinical endocrinology and metabolism200447 influential citations

    Recently, we proposed an oocyte-growth differentiation factor-9 hypothesis that predicts alterations in the initial stages of folliculogenesis in polycystic ovary syndrome (PCOS) ovaries. Here, we test this hypothesis by scoring the…

  7. Effect of melatonin supplementation on cardiometabolic risk factors, oxidative stress and hormonal profile in PCOS patients: a systematic review and meta-analysis of randomized clinical trials.

    J Ovarian Res2024Meta-Analysis47 influential citations

    <h4>Background</h4>To investigate whether melatonin supplementation can enhance cardiometabolic risk factors, reduce oxidative stress, and improve hormonal and pregnancy-related factors in patients with PCOS.<h4>Methods</h4>We conducted a…

  8. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction.

    Gynecol Endocrinol2007n=25Clinical Trial37 influential citations

    <h4>Background</h4>Polycystic ovary syndrome (PCOS) is often characterized by chronic oligo- or anovulation (usually manifested as oligo- or amenorrhea), and hyperandrogenism. In addition, 30-40% of PCOS women have impaired glucose…

  9. Therapeutic effect and safety of curcumin in women with PCOS: A systematic review and meta-analysis.

    Front Endocrinol (Lausanne)2022n=447Meta-Analysis36 influential citations

    Background Polycystic ovary syndrome (PCOS) is a multi-factorial heterogeneous syndrome that has both adverse reproductive and metabolic implications for affected women and its management is a challenging clinical problem. Curcumin, as a…

  10. Effects of ketogenic diet on weight loss parameters among obese or overweight patients with polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trails.

    Food &amp; nutrition research202432 influential citations

    <h4>Aim</h4>To evaluate how effective a low carbohydrate ketogenic diet (KD) is for changing key physical measurements such as weight, waist circumference (WC), body mass index (BMI), and fat mass (FM) in women with polycystic ovary…

Frequently asked

Which population does the evidence apply to?
Most studies investigated: patient.
Are there safety considerations for PCOS?
• No significant adverse effects were reported. • No adverse events were reported in the included trials. • No multiple pregnancy was reported. • Two pregnancies ended in spontaneous abortion.

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