IGF-1Evidence & Dosage
Insulin-like growth factor — growth, anabolism, the longevity trade-off.
Evidence at a glance
- Total studies
- 629
- With abstract
- 47
- Meta / Systematic / RCT
- 1
- Highly cited
- 4
- Publication years
- 1978–2026
IGF-1 in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on IGF-1
Ranked by influential-citation count and publication year.
Growth Hormone and IGF-1 Actions in the Brain and Neuropsychiatric Diseases
Physiology202680 influential citationsGrowth hormone (GH) is secreted by the anterior pituitary gland under the control of hypothalamic neuroendocrine neurons that express somatostatin or growth hormone-releasing hormone (GHRH). Ghrelin, originating primarily in the stomach,…
IGF-1R Inhibitor IBI311 for the Treatment of Active Thyroid Eye Disease in Chinese Patients
JAMA Ophthalmology2025n=5432 influential citations<h4>Importance</h4>Thyroid eye disease (TED), a disfiguring and potentially sight-threatening condition with racial phenotypic variations, currently has limited effective treatments. Insulin-like growth factor 1 receptor (IGF-1R)…
Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival.
Endocrinology200325 influential citationsPrevious studies showed that serum from men consuming a low fat diet and undergoing exercise intervention (DE) reduced LNCaP cell growth and induced apoptosis in vitro. DE also decreased serum IGF-I and increased serum IGF binding…
The regulation of insulin-like growth factor binding protein (IGFBP)-1 during prolonged fasting.
Clinical endocrinology199319 influential citations<h4>Objective</h4>Insulin-like growth factor binding protein (IGFBP)-1 levels increase overnight, being inversely related to changes in insulin. With prolonged fasting IGFBP-1 levels increase further. In animal studies high IGFBP-1 levels…
Epigallocatechin gallate ameliorates oxaliplatin-induced peripheral neuropathy via upregulation of IGF-1 signaling and suppression of neuroinflammation
Neuropharmacology20253 influential citationsChemotherapy-Induced Peripheral Neuropathy (CIPN) is a severe neurological complication characterized by persistent pain and sensory dysfunction. This study investigated the role of Insulin-like Growth Factor-1 (IGF-1) signaling in the…
IGF-1 regulates cancer cell immune evasion in prostate cancer
Scientific Reports20253 influential citationsInsulin-like growth factor-1 (IGF-1) is associated with prostate cancer (PCa) development and lethality and exhibits immunosuppressive properties in other models. We investigated IGF-1's tumor-intrinsic immune effects in PCa to understand…
Low-Intensity pulsed ultrasound enhances paracrine secretion of IGF and VEGF by bmscs, promoting osteogenesis and angiogenesis
BMC Musculoskeletal Disorders20253 influential citations<h4>Background</h4>Low-intensity pulsed ultrasound (LIPUS) is an effective therapy for craniofacial bone regeneration. Paracrine signaling from mesenchymal stem cells (MSCs) plays a critical role in bone repair, but the impact of LIPUS on…
IGF-1R promotes pain-like behavior in rats with myofascial pain syndrome via the PI3K/AKT pathway
Scientific Reports20253 influential citationsMyofascial pain syndrome (MPS) is a common chronic pain condition characterized primarily by the presence of myofascial trigger points (MTrPs). While the insulin-like growth factor-1 receptor (IGF-1R) is known to be upregulated in injured…
Insulin-like Growth Factor 1 (IGF-1) in Hair Regeneration: Mechanistic Pathways and Therapeutic Potential
Current Issues in Molecular Biology20252 influential citationsIGF-1 (insulin-like growth factor 1) is a growth factor primarily secreted by dermal papilla cells on hair-bearing skin that stimulates hair follicle proliferation and vascularization, and promotes the transition to the anagen growth phase…
Modulatory Action of Insulin-like Growth Factor I (IGF-I) on Cortical Activity: Entrainment of Metabolic and Brain Functions
Cells20252 influential citationsInsulin-like growth factor I (IGF-I) is a neurotrophic factor that regulates neurogenesis, synaptogenesis, and neuronal survival. It also enhances neuronal activity and facilitates synaptic plasticity. Additionally, IGF-I plays a critical…
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