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Thyroid & EnergyEvidence & Dosage

How thyroid status shapes fatigue, weight and mental clarity.

Evidence at a glance

Total studies
321
With abstract
48
Meta / Systematic / RCT
2
Highly cited
50
Publication years
1975–2026

Thyroid & Energy in the context of Hormones

This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Thyroid & Energy

Ranked by influential-citation count and publication year.

  1. Molecular aspects of thyroid hormone actions.

    Endocrine reviews2010200 influential citations

    Cellular actions of thyroid hormone may be initiated within the cell nucleus, at the plasma membrane, in cytoplasm, and at the mitochondrion. Thyroid hormone nuclear receptors (TRs) mediate the biological activities of T(3) via…

  2. Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.

    Endocrine reviews2008178 influential citations

    The iodothyronine deiodinases initiate or terminate thyroid hormone action and therefore are critical for the biological effects mediated by thyroid hormone. Over the years, research has focused on their role in preserving serum levels of…

  3. Thyroid hormones in fetal growth and prepartum maturation.

    The Journal of endocrinology2014129 influential citations

    The thyroid hormones, thyroxine (T4) and triiodothyronine (T3), are essential for normal growth and development of the fetus. Their bioavailability in utero depends on development of the fetal hypothalamic-pituitary-thyroid gland axis and…

  4. The mechanism of action of thyroid hormones.

    Annual review of physiology2000119 influential citations

    Thyroid hormone is essential for normal development, differentiation, and metabolic balance. Thyroid hormone action is mediated by multiple thyroid hormone receptor isoforms derived from two distinct genes. The thyroid hormone receptors…

  5. Neurodevelopmental and neurophysiological actions of thyroid hormone.

    Journal of neuroendocrinology2008119 influential citations

    For over 100 years, thyroid hormones have been known to be essential for neonatal neurodevelopment but whether they are required by the foetal brain remains a matter of controversy. For decades, the prevailing view was that thyroid…

  6. Obesity and thyroid function.

    Molecular and cellular endocrinology2010112 influential citations

    A moderate elevation of thyrotropin (TSH) concentrations, which is associated with triiodothyronine (T3) values in or slightly above the upper normal range, is frequently found in obese humans. These alterations seem rather a consequence…

  7. Mechanisms behind the non-thyroidal illness syndrome: an update.

    The Journal of endocrinology201095 influential citations

    The mechanisms behind the changes in serum triiodothyronine (T(3)), thyroxine (T(4)) and TSH that occur in the non-thyroidal illness syndrome (NTIS) are becoming clearer. Induction of a central hypothyroidism occurs due to a diminution in…

  8. Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions.

    Endocrine reviews201493 influential citations

    TRH is a tripeptide amide that functions as a neurotransmitter but also serves as a neurohormone that has a critical role in the central regulation of the hypothalamic-pituitary-thyroid axis. Hypophysiotropic TRH neurons involved in this…

  9. Effect of tri-iodothyronine replacement on the metabolic and pituitary responses to starvation.

    The New England journal of medicine197990 influential citations

    To determine the implication of decreased T3 production during fasting, seven normal men were fasted for 80 hours on two occasions; they received 5 microgram of T3 every three hours durnig the second fast. The mean serum T3 concentration…

  10. The thyroid-brain interaction in thyroid disorders and mood disorders.

    Journal of neuroendocrinology200889 influential citations

    Thyroid hormones play a critical role in the metabolic activity of the adult brain, and neuropsychiatric manifestations of thyroid disease have long been recognised. However, it is only recently that methodology such as functional…

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