Hormone

LeptinStudienlage & Dosis

Sättigungs-Hormon, Leptinresistenz bei Adipositas.

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 38
Meta / Systematic / RCT: 0
Häufig zitiert: 8
Erscheinungsjahre: 1998–2026

Leptin im Kontext von Hormone

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Top-Studien zu Leptin

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Minireview: adiposity, inflammation, and atherogenesis.
Endocrinology2003141 einflussreiche Zitationen
Adipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now…
Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies.
The Journal of clinical endocrinology and metabolism2003n=12186 einflussreiche Zitationen
Adiponectin is an adipocyte-secreted protein that circulates in high concentrations in the serum and acts to increase insulin sensitivity. Previous studies have shown that serum adiponectin is inversely associated with fat mass and insulin…
20 years of leptin: human disorders of leptin action.
The Journal of endocrinology201466 einflussreiche Zitationen
The discovery of leptin has provided a robust framework upon which our current understanding of the mechanisms involved in energy homeostasis has been built. In this review, we describe how the identification of humans with mutations in…
The Leptin Receptor Complex: Heavier Than Expected?
Frontiers in endocrinology201756 einflussreiche Zitationen
Under normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight by balancing food intake and energy expenditure. However, this adipocyte-derived hormone also directs peripheral processes, including…
Adiponectin in anorexia nervosa and bulimia nervosa.
The Journal of clinical endocrinology and metabolism2004n=1328 einflussreiche Zitationen
To study the role of adiponectin, a novel adipocyte-specific secreted protein, on the pathophysiology of eating disorders, circulating levels of fasting adiponectin, leptin, insulin, and glucose were measured in 31 female patients with…
The complex effects of leptin on bone metabolism through multiple pathways.
Current opinion in pharmacology200425 einflussreiche Zitationen
Leptin has recently emerged as a mediator of the protective effects of fat on bone tissue. However, it remains difficult to draw a clear picture of how leptin effects bone metabolism. From conflicting or apparently contradictory data, it…
A novel pathophysiologic phenomenon in cachexic patients with chronic obstructive pulmonary disease: the relationship between the circadian rhythm of circulating leptin and the very low-frequency component of heart rate variability.
Am J Respir Crit Care Med2001n=24Study20 einflussreiche Zitationen
Cachexic patients with chronic obstructive pulmonary disease (COPD) show abnormalities of the autonomic nervous system (ANS), neuroendocrine function, and energy expenditure. Leptin has been implicated in the regulation of ANS,…
Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.
PloS one2012n=10220 einflussreiche Zitationen
<h4>Background</h4>Visceral obesity is associated with the rising incidence of type 2 diabetes and metabolic syndrome. Low-grade chronic inflammation and oxidative stress synergize in obesity and obesity-induced…
Toll-like receptors: linking inflammation to metabolism.
Trends in endocrinology and metabolism: TEM20114 einflussreiche Zitationen
Obesity has been characterized as a state of chronic inflammation. Inflammatory signaling not only causes peripheral insulin resistance, but also promotes neuronal insulin and leptin resistance, which further propagates a positive energy…
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
Cell Metabolism20264 einflussreiche Zitationen
The exact mechanisms underlying leptin resistance, the central mechanism of obesity, remain elusive. Herein, we demonstrate that adipocyte-derived extracellular vesicles (Ad-EVs) serve as key regulatory factors of hypothalamic circuits…