LeptinEvidence & Dosage
Satiety hormone, leptin resistance in obesity.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 38
- Meta / Systematic / RCT
- 0
- Highly cited
- 8
- Publication years
- 1998–2026
Leptin in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on Leptin
Ranked by influential-citation count and publication year.
Minireview: adiposity, inflammation, and atherogenesis.
Endocrinology2003141 influential citationsAdipose tissue is a dynamic endocrine organ that secretes a number of factors that are increasingly recognized to contribute to systemic and vascular inflammation. Several of these factors, collectively referred to as adipokines, have now…
Serum adiponectin levels are inversely associated with overall and central fat distribution but are not directly regulated by acute fasting or leptin administration in humans: cross-sectional and interventional studies.
The Journal of clinical endocrinology and metabolism2003n=12186 influential citationsAdiponectin is an adipocyte-secreted protein that circulates in high concentrations in the serum and acts to increase insulin sensitivity. Previous studies have shown that serum adiponectin is inversely associated with fat mass and insulin…
20 years of leptin: human disorders of leptin action.
The Journal of endocrinology201466 influential citationsThe discovery of leptin has provided a robust framework upon which our current understanding of the mechanisms involved in energy homeostasis has been built. In this review, we describe how the identification of humans with mutations in…
The Leptin Receptor Complex: Heavier Than Expected?
Frontiers in endocrinology201756 influential citationsUnder normal physiological conditions, leptin and the leptin receptor (ObR) regulate the body weight by balancing food intake and energy expenditure. However, this adipocyte-derived hormone also directs peripheral processes, including…
Adiponectin in anorexia nervosa and bulimia nervosa.
The Journal of clinical endocrinology and metabolism2004n=1328 influential citationsTo study the role of adiponectin, a novel adipocyte-specific secreted protein, on the pathophysiology of eating disorders, circulating levels of fasting adiponectin, leptin, insulin, and glucose were measured in 31 female patients with…
The complex effects of leptin on bone metabolism through multiple pathways.
Current opinion in pharmacology200425 influential citationsLeptin has recently emerged as a mediator of the protective effects of fat on bone tissue. However, it remains difficult to draw a clear picture of how leptin effects bone metabolism. From conflicting or apparently contradictory data, it…
A novel pathophysiologic phenomenon in cachexic patients with chronic obstructive pulmonary disease: the relationship between the circadian rhythm of circulating leptin and the very low-frequency component of heart rate variability.
Am J Respir Crit Care Med2001n=24Study20 influential citationsCachexic patients with chronic obstructive pulmonary disease (COPD) show abnormalities of the autonomic nervous system (ANS), neuroendocrine function, and energy expenditure. Leptin has been implicated in the regulation of ANS,…
Interleukin-1 receptor-associated kinase-3 is a key inhibitor of inflammation in obesity and metabolic syndrome.
PloS one2012n=10220 influential citations<h4>Background</h4>Visceral obesity is associated with the rising incidence of type 2 diabetes and metabolic syndrome. Low-grade chronic inflammation and oxidative stress synergize in obesity and obesity-induced…
Toll-like receptors: linking inflammation to metabolism.
Trends in endocrinology and metabolism: TEM20114 influential citationsObesity has been characterized as a state of chronic inflammation. Inflammatory signaling not only causes peripheral insulin resistance, but also promotes neuronal insulin and leptin resistance, which further propagates a positive energy…
Adipocyte-derived extracellular vesicles are key regulators of central leptin sensitivity and energy homeostasis
Cell Metabolism20264 influential citationsThe exact mechanisms underlying leptin resistance, the central mechanism of obesity, remain elusive. Herein, we demonstrate that adipocyte-derived extracellular vesicles (Ad-EVs) serve as key regulatory factors of hypothalamic circuits…
Frequently asked
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