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Lion's Mane (Hericium)Evidence & Dosage

Nerve growth factor (NGF), neuroprotection, and dementia studies.

Studies last updated

Evidence at a glance

Total studies
490
With abstract
48
Meta / Systematic / RCT
7
Highly cited
50
Publication years
1990–2026

Lion's Mane (Hericium) in the context of Cognition

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Top studies on Lion's Mane (Hericium)

Ranked by influential-citation count and publication year.

  1. Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.

    Molecules2023review200 influential citations

    Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach. ex Pers.) Pilát), Cordyceps (Ophiocordyceps sinensis (Berk.) G.H. Sung, J.M.…

  2. Mushrooms as Nutritional Powerhouses: A Review of Their Bioactive Compounds, Health Benefits, and Value-Added Products.

    Foods2025Review151 influential citations

    Mushrooms are known to be a nutritional powerhouse, offering diverse bioactive compounds that promote and enhance health. Mushrooms provide a distinguishable taste and aroma and are an essential source of vitamin D<sub>2</sub>, vitamin B…

  3. The chemical structures, biosynthesis, and biological activities of secondary metabolites from the culinary-medicinal mushrooms of the genus Hericium: a review.

    Chin J Nat Med2024Review125 influential citations

    Fungal phytochemicals derived from higher fungi, particularly those from the culinary-medicinal genus Hericium, have gained significant attention in drug discovery and healthcare. This review aims to provide a comprehensive analysis of the…

  4. Neurotrophic and Neuroprotective Effects of Hericium erinaceus.

    Int J Mol Sci2023review98 influential citations

    Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes,…

  5. Chemistry, Nutrition, and Health-Promoting Properties of Hericium erinaceus (Lion's Mane) Mushroom Fruiting Bodies and Mycelia and Their Bioactive Compounds.

    J Agric Food Chem2015review91 influential citations

    The culinary and medicinal mushroom Hericium erinaceus is widely consumed in Asian countries, but apparently not in the United States, for its nutritional and health benefits. To stimulate broader interest in the reported beneficial…

  6. Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential-A Narrative Review.

    Nutrients2025review87 influential citations

    Hericium erinaceus, commonly known as lion's mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a…

  7. Hericium erinaceus polysaccharides ameliorate nonalcoholic fatty liver disease via gut microbiota and tryptophan metabolism regulation in an aged laying hen model.

    Int J Biol Macromol2024Study83 influential citations

    Polysaccharides extracted from Hericium erinaceus (HEP) exhibit hepatoprotective activity in the alleviation of non-alcoholic fatty liver disease (NAFLD); however, the mechanisms underlying whether and how HEP regulation of the gut…

  8. Structures, biological activities, and industrial applications of the polysaccharides from Hericium erinaceus (Lion's Mane) mushroom: A review.

    Int J Biol Macromol2017Review78 influential citations

    Hericium erinaceus (Bull.) Pers., also known as Yamabushitake, Houtou and Lion's Mane, is capable of fortifying the spleen and nourishing the stomach, tranquilizing the mind, and fighting cancer. Over the past decade, it has been…

  9. Recent developments in Hericium erinaceus polysaccharides: extraction, purification, structural characteristics and biological activities.

    Crit Rev Food Sci Nutr2019Review77 influential citations

    <i>Hericium erinaceus</i> (<i>H. erinaceus</i>), an edible mushroom with medicinal value, has a long history of usage in China and other oriental countries. Polysaccharide is supposed to be one of the major bioactive compounds in <i>H.…

  10. Hericium erinaceus in Neurodegenerative Diseases: From Bench to Bedside and Beyond, How Far from the Shoreline?

    J Fungi (Basel)2023Review77 influential citations

    A growing number of studies is focusing on the pharmacology and feasibility of bioactive compounds as a novel valuable approach to target a variety of human diseases related to neurological degeneration. Among the group of the so-called…

Frequently asked

Are there safety considerations for Lion's Mane (Hericium)?
• Toxicology studies reported no toxicity/morbidity/mortality up to 3 g/kg for 28 days in rats. • A β-glucan extract had a NOAEL of 2000 mg/kg/day in Sprague-Dawley rats. • Some clinical reports in the review stated no adverse effects or no treatment-related toxicity. • High doses of H. erinaceus did not show neuroprotective benefit in one seizure model, suggesting an optimal dose range.

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