MelatoninEvidence & Dosage
Sleep hormone, antioxidant, daylight synchronization — the low-dose recommendation.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 47
- Meta / Systematic / RCT
- 6
- Highly cited
- 31
- Publication years
- 1963–2026
Melatonin in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on Melatonin
Ranked by influential-citation count and publication year.
Effect of melatonin on the reproductive systems of male and female Syrian hamsters: a diurnal rhythm in sensitivity to melatonin.
Endocrinology1976169 influential citationsHamsters were maintained on a long photoperiod (14L:10D) and were injected once daily with melatonin (10-25 mug) or sesame oil. Males which received melatonin during the afternoon (e.g., 6.5-13.75 h after lights-on) showed regressed testes…
Significance of melatonin in antioxidative defense system: reactions and products.
Biological signals and receptors2000125 influential citationsMelatonin is a potent endogenous free radical scavenger, actions that are independent of its many receptor-mediated effects. In the last several years, hundreds of publications have confirmed that melatonin is a broad-spectrum antioxidant.…
Effect of tart cherry juice (Prunus cerasus) on melatonin levels and enhanced sleep quality.
Eur J Nutr2012n=20rct63 influential citationsBACKGROUND: Tart Montmorency cherries have been reported to contain high levels of phytochemicals including melatonin, a molecule critical in regulating the sleep-wake cycle in humans. PURPOSE: The aim of our investigation was to ascertain…
Ocular and systemic melatonin and the influence of light exposure.
Clin Exp Optom2019review57 influential citationsMelatonin is a neurohormone known to modulate a wide range of circadian functions, including sleep. The synthesis and release of melatonin from the pineal gland is heavily influenced by light stimulation of the retina, particularly through…
Do plasma melatonin concentrations decline with age?
The American journal of medicine1999n=2052 influential citations<h4>Purpose</h4>Numerous reports that secretion of the putative sleep-promoting hormone melatonin declines with age have led to suggestions that melatonin replacement therapy be used to treat sleep problems in older patients. We sought to…
Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men.
The American journal of cardiology199950 influential citationsIn this study it was investigated whether the oral administration of melatonin (1 mg) in comparison to placebo was able to reduce blood pressure, vascular reactivity, and catecholamines in men, as previously reported in young women. The…
Comparing the Effectiveness of Physical Exercise Intervention and Melatonin Supplement in Improving Sleep Quality in Children with ASD.
J Autism Dev Disord2024n=32RCT47 influential citations<h4>Purpose</h4>Previous studies have demonstrated that physical exercise can modulate the endogenous melatonin level in children with autism spectrum disorder (ASD) and improve their sleep quality. However, it remains unclear whether…
Melatonin inhibition of cancer growth in vivo involves suppression of tumor fatty acid metabolism via melatonin receptor-mediated signal transduction events.
Cancer research199944 influential citationsThe growth of rat hepatoma 7288CTC in vivo is stimulated by the uptake of linoleic acid (LA) and its metabolism to 13-hydroxyoctadecadienoic acid (13-HODE), an important mitogenic signaling molecule within this tumor. Conversely, the…
Melatonin increases activities of glutathione peroxidase and superoxide dismutase in fetal rat brain.
Journal of pineal research200038 influential citationsMelatonin is a powerful scavenger of oxygen free radicals. In humans, melatonin is rapidly transferred from the maternal to the fetal circulation. To investigate whether or not maternal melatonin administration can protect the fetal rat…
Melatonin in plants.
Nutrition reviews200136 influential citationsOnce thought to be exclusively a molecule of the animal kingdom, melatonin has now been found to exist in plants as well. Among a number of actions, melatonin is a direct free radical scavenger and an indirect antioxidant. Melatonin…
Frequently asked
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Are there safety considerations for Melatonin?
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