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CRPEvidence & Dosage

C-reactive protein, hs-CRP as an inflammation marker, training's effect.

Studies last updated

Evidence at a glance

Total studies
345
With abstract
49
Meta / Systematic / RCT
108
Highly cited
50
Publication years
2004–2026

CRP in the context of Recovery

This topic is part of our "Recovery" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on CRP

Ranked by influential-citation count and publication year.

  1. Omega-3 Fatty Acid Supplementation on Post-Exercise Inflammation, Muscle Damage, Oxidative Response, and Sports Performance in Physically Healthy Adults-A Systematic Review of Randomized Controlled Trials.

    Nutrients2024n=13systematic175 influential citations

    Omega-3 is a family of n-3 polyunsaturated fatty acids (PUFAs), which have been used to treat a wide variety of chronic diseases, due mainly to their antioxidant and anti-inflammatory properties, among others. In this context, omega-3…

  2. Meta-analysis of short-term outcomes after laparoscopic resection for colorectal cancer.

    Br J Surg2004n=2,512Meta-Analysis159 influential citations

    <h4>Background</h4>The safety and efficacy of laparoscopic resection (LR) for colorectal cancer remains to be established.<h4>Methods</h4>A meta-analysis of randomized clinical trials comparing the short-term outcomes of laparoscopic with…

  3. Routine clinical markers of the magnitude of the systemic inflammatory response after elective operation: a systematic review.

    Surgery2015n=14,362Systematic Review124 influential citations

    <h4>Background</h4>Operative injury to the body from all procedures causes a stereotypical cascade of neuroendocrine, cytokine, myeloid, and acute phase responses. This response has been examined commonly by the use of cortisol,…

  4. The influence of resistance training on inflammatory markers, body composition and functional capacity in healthy older adults: A systematic review and meta-analysis.

    Arch Gerontol Geriatr2025n=728Meta-Analysis99 influential citations

    <h4>Background</h4>Older adults experience chronic inflammation, which is associated with health conditions such as sarcopenia, and resulting in reduced functional capacity. Resistance training (RT) is a beneficial intervention for…

    Finding: In healthy adults aged 60 years and over, resistance training significantly decreased C-reactive protein (CRP) levels.

  5. Effect of phototherapy (low-level laser therapy and light-emitting diode therapy) on exercise performance and markers of exercise recovery: a systematic review with meta-analysis.

    Lasers Med Sci2015Meta-Analysis98 influential citations

    Recent studies have explored if phototherapy with low-level laser therapy (LLLT) or narrow-band light-emitting diode therapy (LEDT) can modulate activity-induced skeletal muscle fatigue or subsequently protect against muscle injury. We…

  6. Effects of Experimental Sleep Deprivation on Peripheral Inflammation: An Updated Meta-Analysis of Human Studies.

    J Sleep Res2026n=887Meta-Analysis60 influential citations

    A precise understanding of the effects of experimental sleep deprivation on inflammation is necessary to refine theoretical perspectives on sleep-related immunopathological processes and implement robust empirical procedures. Here, we…

  7. Effects of Exercise Therapy in Axial Spondyloarthritis: A Systematic Review, Meta-analysis, and Meta-regression of Randomized Trials.

    Arch Phys Med Rehabil2025n=1,670Meta-Analysis57 influential citations

    <h4>Objective</h4>This study aimed to assess the effectiveness of exercise therapy for patients with axial spondyloarthritis (axSpA).<h4>Data sources</h4>We searched MEDLINE (via PubMed), Cochrane Library, Embase, Web of Science, Scopus,…

  8. The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically Ill patients with sepsis: a randomized, double-blind, controlled trial.

    Nutrition journal2024n=6054 influential citations

    <h4>Background</h4>Sepsis, a life-threatening organ dysfunction caused by a host's dysregulated response to infection with an inflammatory process, becomes a real challenge for the healthcare systems. L-carnitine (LC) has antioxidant and…

  9. Risk factors, biomarkers, and mechanisms for persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a systematic review and meta-analysis.

    Br J Anaesth2024n=391Meta-Analysis51 influential citations

    <h4>Introduction</h4>Persistent inflammation, immunosuppression, and catabolism syndrome (PICS) has been proposed as an endotype of chronic critical illness (CCI). The aim of this systematic review is to synthesise the available evidence…

  10. Enhanced recovery versus conventional care in gastric cancer surgery: a meta-analysis of randomized and non-randomized controlled trials.

    Gastric Cancer2019n=2,686Meta-Analysis49 influential citations

    <h4>Introduction</h4>Enhanced recovery after surgery (ERAS) protocols have been successfully integrated into peri-operative management of different cancer surgeries such as colorectal cancer. Their value for gastric cancer surgery,…

Frequently asked

What dosage was studied?
• Omega-3 fatty acid supplementation (EPA/DHA; one study used ALA) (250 mg/day to 6 g/day EPA/DHA; one study up to 31 g/day ALA (0.43 g ALA/kg body mass)) • laparoscopic resection (LR)
Are there safety considerations for CRP?
• Three studies reported no harmful effects from omega-3 supplementation. • GI side effects such as belching, heartburn, stomach pain, vomiting, constipation, diarrhea, nausea, and taste changes were noted in prior studies. • Not reported in abstract.

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