TelomeresEvidence & Dosage
Chromosome ends, telomerase, lifestyle influences, the critical marker debate.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 35
- Meta / Systematic / RCT
- 0
- Highly cited
- 15
- Publication years
- 1988–2026
Telomeres in the context of Longevity
This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to LongevityTop studies on Telomeres
Ranked by influential-citation count and publication year.
DNA damage foci at dysfunctional telomeres.
Current biology : CB2003191 influential citationsWe report cytologic and genetic data indicating that telomere dysfunction induces a DNA damage response in mammalian cells. Dysfunctional, uncapped telomeres, created through inhibition of TRF2, became associated with DNA damage response…
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
Science (New York, N.Y.)2015n=1,556108 influential citationsCancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited…
TRF2 protects human telomeres from end-to-end fusions.
Cell199884 influential citationsThe mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here, we show that the human telomeric protein TRF2 plays a key role in the protective activity of telomeres. A dominant negative allele of TRF2 induced…
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase.
Nucleic acids research201064 influential citationsTelomeres, the physical ends of eukaryotes chromosomes are transcribed into telomeric repeat containing RNA (TERRA), a large non-coding RNA of unknown function, which forms an integral part of telomeric heterochromatin. TERRA molecules…
Telomere functions grounding on TERRA firma.
Trends in cell biology201547 influential citationsLong noncoding telomeric repeat-containing RNAs - TERRAs - are transcribed in a regulated manner from telomeres throughout eukaryotes. TERRA molecules consist of chromosome end-specific subtelomeric sequences and telomeric repeats at their…
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition.
Cancer research200426 influential citationsThe majority of human malignancies use telomerase to maintain telomere homeostasis. Antitelomerase therapy is therefore a promising approach for a cancer-specific therapy. The alternative lengthening of telomeres pathway (ALT) is a…
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.
Molecular and cellular biology200219 influential citationsTelomere maintenance is essential for the continuous growth of tumor cells. In most human tumors telomeres are maintained by telomerase, a specialized reverse transcriptase. Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase…
Telomere dysfunction increases mutation rate and genomic instability.
Cell200113 influential citationsThe increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The mutation rate in the…
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
Nature Communications20169 influential citationsRepressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays important roles in telomere length control and is involved in…
Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity
Science Advances20188 influential citationsTelomeres do not shorten with age in longest-lived bats.
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