Longevity

TelomereStudienlage & Dosis

Chromosomen-Enden, Telomerase, Lifestyle-Einflüsse, kritische Marker-Debatte.

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 35
Meta / Systematic / RCT: 0
Häufig zitiert: 15
Erscheinungsjahre: 1988–2026

Telomere im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

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Top-Studien zu Telomere

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

DNA damage foci at dysfunctional telomeres.
Current biology : CB2003191 einflussreiche Zitationen
We report cytologic and genetic data indicating that telomere dysfunction induces a DNA damage response in mammalian cells. Dysfunctional, uncapped telomeres, created through inhibition of TRF2, became associated with DNA damage response…
Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.
Science (New York, N.Y.)2015n=1.556108 einflussreiche Zitationen
Cancer cells rely on telomerase or the alternative lengthening of telomeres (ALT) pathway to overcome replicative mortality. ALT is mediated by recombination and is prevalent in a subset of human cancers, yet whether it can be exploited…
TRF2 protects human telomeres from end-to-end fusions.
Cell199884 einflussreiche Zitationen
The mechanism by which telomeres prevent end-to-end fusion has remained elusive. Here, we show that the human telomeric protein TRF2 plays a key role in the protective activity of telomeres. A dominant negative allele of TRF2 induced…
The non-coding RNA TERRA is a natural ligand and direct inhibitor of human telomerase.
Nucleic acids research201064 einflussreiche Zitationen
Telomeres, the physical ends of eukaryotes chromosomes are transcribed into telomeric repeat containing RNA (TERRA), a large non-coding RNA of unknown function, which forms an integral part of telomeric heterochromatin. TERRA molecules…
Telomere functions grounding on TERRA firma.
Trends in cell biology201547 einflussreiche Zitationen
Long noncoding telomeric repeat-containing RNAs - TERRAs - are transcribed in a regulated manner from telomeres throughout eukaryotes. TERRA molecules consist of chromosome end-specific subtelomeric sequences and telomeric repeats at their…
Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition.
Cancer research200426 einflussreiche Zitationen
The majority of human malignancies use telomerase to maintain telomere homeostasis. Antitelomerase therapy is therefore a promising approach for a cancer-specific therapy. The alternative lengthening of telomeres pathway (ALT) is a…
Role for the related poly(ADP-Ribose) polymerases tankyrase 1 and 2 at human telomeres.
Molecular and cellular biology200219 einflussreiche Zitationen
Telomere maintenance is essential for the continuous growth of tumor cells. In most human tumors telomeres are maintained by telomerase, a specialized reverse transcriptase. Tankyrase 1, a human telomeric poly(ADP-ribose) polymerase…
Telomere dysfunction increases mutation rate and genomic instability.
Cell200113 einflussreiche Zitationen
The increased tumor incidence in telomerase null mice suggests that telomere dysfunction induces genetic instability. To test this directly, we examined mutation rate in the absence of telomerase in S. cerevisiae. The mutation rate in the…
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
Nature Communications20169 einflussreiche Zitationen
Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein. Yeast Rap1 protects telomeres from non-homologous end joining (NHEJ), plays important roles in telomere length control and is involved in…
Growing old, yet staying young: The role of telomeres in bats’ exceptional longevity
Science Advances20188 einflussreiche Zitationen
Telomeres do not shorten with age in longest-lived bats.