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TB-500Evidence & Dosage

Peptide for accelerated regeneration and wound healing.

Studies last updated

Evidence at a glance

Total studies
449
With abstract
49
Meta / Systematic / RCT
5
Highly cited
50
Publication years
1992–2026

TB-500 in the context of Peptides

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Top studies on TB-500

Ranked by influential-citation count and publication year.

  1. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair.

    Nature2004E107 influential citations

    Heart disease is a leading cause of death in newborn children and in adults. Efforts to promote cardiac repair through the use of stem cells hold promise but typically involve isolation and introduction of progenitor cells. Here, we show…

  2. Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)2025n=5E96 influential citations

    Microneedles loaded with bioactive substances have demonstrated efficacy in wound healing, while their application in the elderly chronic wounds, aggravated by cellular senescence, is still a significant challenge. Here, a novel…

  3. beta-Thymosins, small acidic peptides with multiple functions.

    The international journal of biochemistry & cell biology2001D68 influential citations

    The beta-thymosins are a family of highly conserved polar 5 kDa peptides originally thought to be thymic hormones. About 10 years ago, thymosin beta(4) as well as other members of this ubiquitous peptide family were identified as the main…

  4. Thymosin beta4 accelerates wound healing.

    The Journal of investigative dermatology1999E59 influential citations

    Angiogenesis is an essential step in the repair process that occurs after injury. In this study, we investigated whether the angiogenic thymic peptide thymosin beta4 (Tbeta4) enhanced wound healing in a rat full thickness wound model.…

  5. Thymosin beta4: actin-sequestering protein moonlights to repair injured tissues.

    Trends in molecular medicine2005D52 influential citations

    Here, we review the biochemical and molecular properties of thymosin beta(4) (Tbeta(4)), the major actin-sequestering molecule in eukaryotic cells, and its key role in dermal- and corneal-wound healing. Tbeta(4) has several, novel,…

  6. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury.

    Experimental eye research2002E47 influential citations

    Previously, thymosin beta 4 (Tbeta(4)) was found to promote wound healing in full thickness skin wounds and heptanol debrided corneas. Here, the effect of Tbeta(4) was examined treatment on corneal wound healing and inflammation in vivo…

  7. Thymosin beta 4 stimulates directional migration of human umbilical vein endothelial cells.

    FASEB journal : official publication of the Federation of American Societies for Experimental Biology1997E45 influential citations

    Thymosin beta 4 (T beta 4) is a 4.9 kDa polypeptide that interacts with G-actin and is thought to be an important mediator in cell proliferation, migration, and differentiation. T beta 4 has been identified as a factor involved in the…

  8. Injectable Thymosin β4-Modified Hyaluronic Acid Hydrogel with Exosomes for Stem Cell Homing and Neuronic-Angiogenic-Osteogenic Coupled Cranial Repair.

    ACS Nano2025Study37 influential citations

    Accelerating angiogenesis, neurogenesis, and in situ stem cell recruitment at the site of bone defects is critical for bone regenerative repair. Bone marrow mesenchymal stem cell (BMSC) exosomes are cell-free therapeutic agents with…

  9. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications.

    Expert Opin Biol Ther2012Study35 influential citations

    <h4>Introduction</h4>Thymosin β(4), a low molecular weight, naturally-occurring peptide plays a vital role in the repair and regeneration of injured cells and tissues. After injury, thymosin β(4), is released by platelets, macrophages and…

  10. Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway.

    Experimental eye research2007E33 influential citations

    The purpose of this study was to determine the effect of thymosin beta 4 (Tbeta4) on NFkappaB protein levels, activation, phosphorylation, and nuclear translocation in a model of tumor necrosis factor (TNF)-alpha-mediated corneal…

Frequently asked

What dosage was studied?
• Thymosin β4-modified adipose-derived stem cell extracellular vesicles delivered via separable microneedle patches (MN@EVsTβ4) (not reported)
Are there safety considerations for TB-500?
• not reported • Not reported. • Not reported in the abstract.

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