HypothalamusEvidence & Dosage
Master regulator: temperature, hunger, sleep, hormone control.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 48
- Meta / Systematic / RCT
- 0
- Highly cited
- 30
- Publication years
- 1976–2026
Hypothalamus in the context of Hormones
This topic is part of our "Hormones" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to HormonesTop studies on Hypothalamus
Ranked by influential-citation count and publication year.
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity.
Proceedings of the National Academy of Sciences of the United States of America1998200 influential citationsWe describe a hypothalamus-specific mRNA that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin. The hypocretin (Hcrt) protein products are…
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus.
Nature2004200 influential citationsObesity is an epidemic in Western society, and causes rapidly accelerating rates of type 2 diabetes and cardiovascular disease. The evolutionarily conserved serine/threonine kinase, AMP-activated protein kinase (AMPK), functions as a 'fuel…
Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus.
Endocrinology2005200 influential citationsObesity has reached epidemic proportions in several regions of the world. General changes in lifestyle, including consumption of fat-rich food, are among the most important factors leading to an unprecedented increase in the prevalence of…
Identification of nesfatin-1 as a satiety molecule in the hypothalamus.
Nature2006200 influential citationsThe brain hypothalamus contains certain secreted molecules that are important in regulating feeding behaviour. Here we show that nesfatin, corresponding to NEFA/nucleobindin2 (NUCB2), a secreted protein of unknown function, is expressed in…
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake.
Cell metabolism2007160 influential citationsAdiponectin has been shown to stimulate fatty acid oxidation and enhance insulin sensitivity through the activation of AMP-activated protein kinase (AMPK) in the peripheral tissues. The effects of adiponectin in the central nervous system,…
HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.
Nature metabolism2022158 influential citationsThe hypothalamus plays a key role in coordinating fundamental body functions. Despite recent progress in single-cell technologies, a unified catalog and molecular characterization of the heterogeneous cell types and, specifically, neuronal…
Identification of targets of leptin action in rat hypothalamus.
Journal of Clinical Investigation199673 influential citationsThe hypothesis that leptin (OB protein) acts in the hypothalamus to reduce food intake and body weight is based primarily on evidence from leptin-deficient, ob/ob mice. To investigate whether leptin exerts similar effects in normal…
Sleep and the hypothalamus.
Science (New York, N.Y.)202372 influential citationsNeural substrates of wakefulness, rapid eye movement sleep (REMS), and non-REMS (NREMS) in the mammalian hypothalamus overlap both anatomically and functionally with cellular networks that support physiological and behavioral homeostasis.…
Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal cord in the rat
The Journal of comparative neurology198247 influential citationsA method that allows the concurrent localization of an antigen and a retrogradely transported fluorescent dye (true blue) was used to identify, immunohistochemically, cells in the paraventricular nucleus of the hypothalamus (PVH) that…
Functional identification of an aggression locus in the mouse hypothalamus
Nature201046 influential citationsElectrical stimulation of certain hypothalamic regions in cats and rodents can elicit attack behaviour, but the exact location of relevant cells within these regions, their requirement for naturally occurring aggression and their…
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