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Vitamins & Minerals

QuercetinEvidence & Dosage

Allergies, senolytic properties, bioflavonoids and combination with bromelain.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
125
Highly cited
50
Publication years
1997–2026

Quercetin in the context of Vitamins & Minerals

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Top studies on Quercetin

Ranked by influential-citation count and publication year.

  1. A Systematic Review: Quercetin-Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability.

    Int J Mol Sci2024n=405Systematic Review163 influential citations

    The main goal of this systematic review on the flavonol class secondary metabolite quercetin is to evaluate and summarize the existing research on quercetin's potential health benefits, therapeutic properties, and effectiveness in disease…

  2. Improving quercetin bioavailability: A systematic review and meta-analysis of human intervention studies.

    Food Chem2025n=31Meta-Analysis138 influential citations

    This systematic review evaluated a total of 31 included human intervention studies that have assessed methods to improve quercetin bioavailability from different formulations and food matrices using urine or blood samples up to July 2024.…

  3. Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review.

    Nutrients2022n=36Systematic Review129 influential citations

    Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant…

  4. In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature.

    Biomed Pharmacother2019Systematic Review116 influential citations

    Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to…

  5. Preclinical evidence of reno-protective effect of quercetin on acute kidney injury: a meta-analysis of animal studies.

    Front Pharmacol2023n=288Systematic Review115 influential citations

    Objective: This study evaluated the reno-protective effects of quercetin in animal models of acute kidney injury (AKI). Methods: We conducted a systematic search of literature published before April 2023 in PubMed, Web of Science, and…

  6. Effects of Quercetin on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

    J Am Heart Assoc2016n=587Meta-Analysis104 influential citations

    Background Quercetin, the most abundant dietary flavonol, has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure ( BP ) has not been conclusive. We assessed the impact of quercetin on BP…

  7. Targeting pyroptosis: A novel strategy of ginseng for the treatment of diabetes and its chronic complications.

    Phytomedicine2025Systematic Review98 influential citations

    <h4>Background</h4>Pyroptosis is a recently identified form of programmed cell death that plays a crucial role in the pathogenesis and progression of diabetes and associated chronic complications, while the occurrence mechanism remains…

  8. Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review.

    Curr Top Med Chem2021n=84Systematic Review94 influential citations

    BACKGROUND: Type 2 diabetes (adult onset diabetes) is the most common type of diabetes, accounting for around 90% of all diabetes cases with insulin resistance and insulin secretion defect. The key goal of anti-diabetic therapy is to…

  9. Therapeutic potential of traditional Chinese medicine in the prevention and treatment of digestive inflammatory cancer transformation: Portulaca oleracea L. as a promising drug.

    J Ethnopharmacol2024Meta-Analysis79 influential citations

    <h4>Ethnopharmacological relevance</h4>Traditional Chinese medicine (TCM) has been used for centuries to treat various types of inflammation and tumors of the digestive system. Portulaca oleracea L. (POL), has been used in TCM for…

    Finding: The review suggests that Portulaca oleracea L. compounds may help improve NASH and NASH-HCC.

  10. Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies-An Update Overview.

    Molecules2023Systematic Review74 influential citations

    This review article describes studies published over the past five years on the combination of polyphenols, which are the most studied in the field of anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and…

Frequently asked

What dosage was studied?
• Quercetin and quercetin-based delivery systems (Varies by included studies; examples include 730 mg/day, 1000–1500 mg/day, 25 mg/kg, 0.1 nmol/kg, 100–500 mg/day) • Quercetin from different formulations and food matrices intended to improve bioavailability (Not reported) • Resveratrol, curcumin, and quercetin supplementation (Not reported)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Quercetin?
• Quercetin is contraindicated in pregnant or breastfeeding women and people with kidney disease. • May reduce efficacy of quinolone antibiotics by competing at bacterial DNA gyrase. • May increase toxicity of CYP3A4 substrates such as statins and some antidepressants. • May alter pharmacokinetics of P-glycoprotein substrates, including immunosuppressants.

Related articles

Blog

Quercetin: Effects on Allergies, Mast Cells, and the Immune System

Quercetin is used for its possible effects on allergies and mast cells, but the data are mixed and bioavailability is a key problem. Here is the evidence.

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