Kidneys & HydrationEvidence & Dosage
GFR, electrolytes, hydration, over-/underhydration, acid-base balance.
Evidence at a glance
- Total studies
- 224
- With abstract
- 50
- Meta / Systematic / RCT
- 0
- Highly cited
- 50
- Publication years
- 1979–2026
Kidneys & Hydration in the context of Vitamins & Minerals
This topic is part of our "Vitamins & Minerals" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to Vitamins & MineralsTop studies on Kidneys & Hydration
Ranked by influential-citation count and publication year.
Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.
Kidney international2002n=16200 influential citations<h4>Background</h4>Traditional blood and urine markers for the diagnosis of various renal diseases are insensitive and nonspecific. Kidney Injury Molecule-1 (KIM-1) is a type 1 transmembrane protein, with an immunoglobulin and mucin…
Calcineurin inhibitor nephrotoxicity.
Clinical journal of the American Society of Nephrology : CJASN2009200 influential citationsThe use of the calcineurin inhibitors cyclosporine and tacrolimus led to major advances in the field of transplantation, with excellent short-term outcome. However, the chronic nephrotoxicity of these drugs is the Achilles' heel of current…
Elevated uric acid increases blood pressure in the rat by a novel crystal-independent mechanism.
Hypertension (Dallas, Tex. : 1979)2001n=69200 influential citationsAn elevation in circulating serum uric acid is strongly associated with the development of hypertension and renal disease, but whether uric acid has a causal role or whether it simply indicates patients at risk for these complications…
Acute kidney injury: an increasing global concern.
Lancet (London, England)2013200 influential citationsDespite an increasing incidence of acute kidney injury in both high-income and low-income countries and growing insight into the causes and mechanisms of disease, few preventive and therapeutic options exist. Even small acute changes in…
Mechanisms of maladaptive repair after AKI leading to accelerated kidney ageing and CKD.
Nature reviews. Nephrology2015200 influential citationsAcute kidney injury is an increasingly common complication of hospital admission and is associated with high levels of morbidity and mortality. A hypotensive, septic, or toxic insult can initiate a cascade of events, resulting in impaired…
Drug-Induced Acute Kidney Injury.
Clinical journal of the American Society of Nephrology : CJASN2022200 influential citationsMedications are a common cause of AKI, especially for patients admitted to hospital wards and the intensive care unit. Although drug-related kidney injury occurs through different mechanisms, this review will focus on three specific types…
Kidney Stone Pathophysiology, Evaluation and Management: Core Curriculum 2023.
American journal of kidney diseases : the official journal of the National Kidney Foundation2023200 influential citationsKidney stone disease, also known as nephrolithiasis or urolithiasis, is a disorder in which urinary solutes precipitate to form aggregates of crystalline material in the urinary space. The incidence of nephrolithiasis has been increasing,…
Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: lessons from RENAAL.
Kidney international2004194 influential citations<h4>Background</h4>Proteinuria or albuminuria is an established risk marker for progressive renal function loss. Albuminuria can be effectively lowered with antihypertensive drugs that interrupt the renin-angiotensin system (RAS). We…
Raising awareness of acute kidney injury: a global perspective of a silent killer.
Kidney international2013n=1,500194 influential citationsWorldwide, acute kidney injury (AKI) is associated with poor patient outcomes. Over the last few years, collaborative efforts, enabled by a common definition of AKI, have provided a description of the epidemiology, natural history, and…
Acute Kidney Injury: Medical Causes and Pathogenesis.
Journal of clinical medicine2023n=686193 influential citationsAcute kidney injury (AKI) is a common clinical syndrome characterized by a sudden decline in or loss of kidney function. AKI is not only associated with substantial morbidity and mortality but also with increased risk of chronic kidney…
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