Back to Peptides
Peptides

Peptide BasicsEvidence & Dosage

Amino-acid chains under 50 residues, signaling peptides, hormones — how they differ from proteins.

Evidence at a glance

Total studies
84
With abstract
43
Meta / Systematic / RCT
1
Highly cited
3
Publication years
2024–2026

Peptide Basics in the context of Peptides

This topic is part of our "Peptides" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

Go to Peptides

Top studies on Peptide Basics

Ranked by influential-citation count and publication year.

  1. De novo design of self-assembling peptides with antimicrobial activity guided by deep learning.

    Nature materials2025180 influential citations

    Bioinspired materials based on self-assembling peptides are promising for tackling various challenges in biomedical engineering. While contemporary data-driven approaches have led to the discovery of self-assembling peptides with various…

  2. The Impact of Glucagon-Like Peptide-1 Receptor Agonist Use on Clinical Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis of 346,899 Patients

    The Journal of Arthroplasty202630 influential citations

    <h4>Background</h4>Obesity and diabetes are highly prevalent comorbidities in patients undergoing total hip (THA) and knee arthroplasty (TKA). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are novel agents that promote weight loss…

  3. Effects of PEGylation on Imaging Contrast of 68 Ga-Labeled Bicyclic Peptide PET Probes Targeting Nectin-4.

    Molecular pharmaceutics202422 influential citations

    Nectin cell adhesion molecule 4 (Nectin-4) is overexpressed in various malignant tumors and has emerged as a promising target for tumor imaging. Bicyclic peptides, known for their conformational rigidity, metabolic stability, and membrane…

  4. Improving GRPR-targeting peptides for radiotheranostics application: insights from chelator modifications and α-methyl-L tryptophan substitution.

    2025n=71 influential citations

    <h4>Background</h4>Targeting the gastrin-releasing peptide receptor (GRPR) is a promising approach for radionuclide therapy in prostate and breast cancers. GRPR-targeting peptides often have limited metabolic stability, which can…

  5. Glucagon-like Peptide-1 Receptor Agonists and Risk of Nonarteritic Anterior Ischemic Optic Neuropathy: Systematic Review and Meta-Analysis.

    Neurology2026n=1,593,554Meta-Analysis

    <h4>Background and objectives</h4>Recent observational studies have reported conflicting evidence regarding an association between glucagon-like peptide-1 receptor agonists (GLP-1RAs), particularly semaglutide, and nonarteritic anterior…

  6. Hydrogen bonding and membrane anchoring of the antimicrobial peptide NP-3a investigated through molecular dynamics

    Computational Biology and Chemistry2026

    Antimicrobial peptides (AMPs) are emerging as critical alternatives to antibiotics in the fight against multidrug resistance. NP-3a, a rabbit defensin, combines structural stability with broad-spectrum activity, yet its molecular mechanism…

  7. Identification of Novel Anti- non-small cell lung cancer (NSCLC) Peptide in toad Skin（Chan Pi） Extract through Integrated Peptidomics and in silico Screening

    Journal of Pharmaceutical and Biomedical Analysis2026

    Toad skin (Bufo bufo gargarizans Cantor), known as Chan Pi in traditional Chinese medicine, has long been recognized for its therapeutic potential, particularly in cancer treatment. While the pharmacological activities of small molecules…

  8. Bifunctional peptide-conjugated vertically aligned tubular nanofibrous conduits for enhanced vascularization and nerve regeneration

    Biomaterials Advances2026

    Nerve Guidance Conduits (NGCs) are crucial for reducing trauma during nerve repair, directing axonal growth, and preventing scar tissue formation. In this study, tubular functional NGCs were developed based on vertically aligned…

  9. From generation to validation: Deep generative models for antimicrobial peptide discovery

    Current Opinion in Chemical Biology2026

    The global escalation of antibiotic resistance has renewed interest in antimicrobial peptides (AMPs) as promising alternatives to conventional antibiotics. Although extensive experimental evidence supports their effectiveness against…

  10. Recapitulating tumor extracellular matrix alignment to decipher its role in eliciting malignant cell phenotypes using a peptide liquid crystal hydrogel

    Biomaterials2026

    The aligned microarchitecture of extracellular matrix (ECM) has been recognized as a significant and novel hallmark of certain tumors, which is gradually uncovered to relate to their malignant progression. However, most artificial…

Frequently asked

Are there safety considerations for Peptide Basics?
• Semaglutide use was associated with increased NAION risk versus non-GLP-1RA use. • The association was stronger among patients with diabetes. • Authors advise risk-benefit discussion and further investigation.

More topics in Peptides

Peptides Overview

Peptides, BPC-157, TB-500, safety and the state of the evidence.

Administration Routes

Subcutaneous, intramuscular, nasal, oral, topical — bioavailability and safety.

Autoimmunity Risk

Immune modulation can both promote tolerance and tip into dysregulation.

BPC-157

Peptide for tissue regeneration, healing, and athletic recovery.

Cerebrolysin

A pig-brain peptide mix, stroke studies, not approved in Germany.

CJC-1295

GHRH analog, half‑life variants and pulse patterns.

Dihexa

Angiotensin derivative, cognitive/neuroplasticity signals in animal models.

GHK-Cu

Copper peptide for skin health, anti-aging, and wound healing.

GHRP-2

GH releaser, older generation, appetite stimulation as a side effect.

GHRP-6

GH releaser with a strong appetite component.

GLP-1 Rebound

Weight regain after stopping without lifestyle anchors.

GLP-1 Side Effects

Nausea, gastric emptying, muscle loss, pancreatitis risk.

Hexarelin

GH releaser, fast tolerance build-up, cardiac signals.

IGF-1 LR3

Modified IGF-1 with a long half-life — hypertrophy, the cancer-risk debate.

Immune Modulation

Automatisch via Trend Scout entdeckt. Supplements targeting inflammation and immune resilience remain a central research area.. PubMed: 11956 Ergebnisse.

Injection Safety

Sterile technique, bacteriostatic water, skin disinfection — a medical topic.

Ipamorelin

Selective GH releaser, cortisol‑sparing, and stack combinations.

KPV

An alpha-MSH fragment — anti-inflammatory, gut, skin, early research.

Liraglutide

First-generation GLP-1 for diabetes/obesity — daily, smaller effect size.

LL-37

Antimicrobial peptide, wound healing, immune modulation, early research.

Related topics from other worlds

Mental

Fight/Flight/Freeze

Stress-response patterns, somatic manifestation, regulation.

Mental

Meditation / Mindfulness

MBSR, telomeres, stress reduction, and brain structure effects.

Mental

Resilience

Trainable stress tolerance — factors, practices, mindset.

Mental

St. John's Wort

Hypericin, mild depression, and CYP3A4 interactions.

Performance

ATP System

Phosphagen system, anaerobic glycolysis, oxidative phosphorylation.

Performance

Deload

Planned recovery periods — avoiding overreaching.