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ResveratrolEvidence & Dosage

Sirtuins, cardiovascular, pterostilbene comparison and dosage evidence.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
49
Meta / Systematic / RCT
142
Highly cited
50
Publication years
1999–2026

Resveratrol in the context of Vitamins & Minerals

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Top studies on Resveratrol

Ranked by influential-citation count and publication year.

  1. Resveratrol for the Management of Human Health: How Far Have We Come? A Systematic Review of Resveratrol Clinical Trials to Highlight Gaps and Opportunities.

    Int J Mol Sci2024n=6,126Systematic Review200 influential citations

    Resveratrol has long been proposed as being beneficial to human health across multiple morbidities, yet there is currently no conclusive clinical evidence to advocate its recommendation in any healthcare setting. A large cohort with…

  2. Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review.

    Nutrients2022n=36Systematic Review129 influential citations

    Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin have recently received the most attention among these molecules due to their documented antioxidant…

  3. Pharmacological approaches to enhance mitochondrial biogenesis: focus on PGC-1Α, AMPK, and SIRT1 in cellular health.

    Mol Biol Rep2025Systematic Review109 influential citations

    <h4>Background</h4>Mitochondrial biogenesis is essential for cellular energy balance and metabolic stability. Its dysregulation is linked to various metabolic and neurodegenerative diseases, making it a significant therapeutic target.…

  4. A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health.

    Nutr Res2020Systematic Review92 influential citations

    The potential benefits of supplemental nutrients and dietary interventions against cardiovascular morbidity and mortality have been extensively investigated throughout the years. Numerous supplements claim cardioprotection and reduction of…

  5. Resveratrol Bioavailability After Oral Administration: A Meta-Analysis of Clinical Trial Data.

    Phytother Res2025n=84Meta-Analysis84 influential citations

    Annually, a growing body of studies substantiates the health advantages of polyphenolic compounds, yet their practical application is constrained by swift metabolism and low bioavailability. Resveratrol, a stilbene derivative showcasing…

    Finding: In healthy adults, oral resveratrol administration showed a linear increase in free resveratrol entering the bloodstream with increasing dose.

  6. Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis.

    Front Immunol2022n=2,173meta77 influential citations

    BACKGROUND: Dietary polyphenol treatment of non-alcoholic fatty liver disease (NAFLD) is a novel direction, and the existing clinical studies have little effective evidence for its therapeutic effect, and some studies have inconsistent…

  7. A Systematic Review on the Molecular Mechanisms of Resveratrol in Protecting Against Osteoporosis.

    Int J Mol Sci2025n=28Systematic Review75 influential citations

    Osteoporosis is a prevalent metabolic bone disorder characterized by decreased bone mineral density and increased fracture risk, particularly among aging populations. While conventional pharmacological treatments exist, they often have…

  8. Combination Chemotherapy with Selected Polyphenols in Preclinical and Clinical Studies-An Update Overview.

    Molecules2023Systematic Review74 influential citations

    This review article describes studies published over the past five years on the combination of polyphenols, which are the most studied in the field of anticancer effects (curcumin, quercetin, resveratrol, epigallocatechin gallate, and…

  9. Benefits and Implications of Resveratrol Supplementation on Microbiota Modulations: A Systematic Review of the Literature.

    Int J Mol Sci2022n=18Systematic Review68 influential citations

    Resveratrol is a polyphenol that has been shown to possess many applications in different fields of medicine. This systematic review has drawn attention to the axis between resveratrol and human microbiota, which plays a key role in…

  10. Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence.

    Nutrients2018n=180Systematic Review67 influential citations

    Non-alcoholic fatty liver disease (NAFLD) is a clinical condition characterized by lipid infiltration of the liver, highly prevalent in the general population affecting 25% of adults, with a doubled prevalence in diabetic and obese…

Frequently asked

What dosage was studied?
• Purified resveratrol (Defined doses; generally tolerated up to 1 g/day) • Resveratrol, curcumin, and quercetin supplementation (Not reported) • Resveratrol (Not reported)
Are there safety considerations for Resveratrol?
• Generally well-tolerated at doses up to 1 g/day. • Not reported • Not reported in abstract. • Not reported in the abstract.

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