Telomere LengtheningStudienlage & Dosis

Top-Studien zu Telomere Lengthening

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Telomere Length and All-Cause Mortality: A Meta-analysis.

   Ageing Res Rev·2018·n=121.749Meta-Analysis112 einflussreiche Zitationen

   Telomere attrition is associated with increased morbidity and mortality of various age-related diseases. Reports of association between telomere length (TL) and all-cause mortality remain inconsistent. In the present study, a meta-analysis…

2. 02

   Body mass index is negatively associated with telomere length: a collaborative cross-sectional meta-analysis of 87 observational studies.

   Am J Clin Nutr·2018·n=146.114Meta-Analysis64 einflussreiche Zitationen

   <h4>Background</h4>Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the life course. Obesity may therefore contribute to…

   Befund: In the pooled sample, each 1-unit increase in BMI was associated with a shorter absolute leukocyte telomere length by -3.99 bp.

3. 03

   The Effect of Nutrition on Aging-A Systematic Review Focusing on Aging-Related Biomarkers.

   Nutrients·2022·n=36Systematic Review60 einflussreiche Zitationen

   Despite the increasing life expectancy, an individual’s later years tends to be accompanied by a decrease in the quality of life. Though biological changes that occur through the natural process of aging cannot be controlled, the risk…

4. 04

   Adverse childhood experiences, epigenetics and telomere length variation in childhood and beyond: a systematic review of the literature.

   Eur Child Adolesc Psychiatry·2020·n=849Systematic Review59 einflussreiche Zitationen

   A systematic review following PRISMA guidelines was conducted to answer the question: What epigenetic, telomeric and associated biological changes are associated with exposure to adverse childhood experiences (ACEs) in the under 12s? Using…

5. 05

   Telomere length predicts poststroke mortality, dementia, and cognitive decline.

   Annals of neurology·200652 einflussreiche Zitationen

   <h4>Objective</h4>Long-term cognitive development is variable among stroke survivors, with a high proportion developing dementia. Early identification of those at risk is highly desirable to target interventions for secondary prevention.…

6. 06

   Impact of Nutrition on Telomere Health: Systematic Review of Observational Cohort Studies and Randomized Clinical Trials.

   Adv Nutr·2020Systematic Review50 einflussreiche Zitationen

   Diet, physical activity, and other lifestyle factors have been implicated in the pathophysiology of several chronic diseases, but also in a lower total mortality and longer life expectancy. One of the mechanisms in which diet can reduce…

7. 07

   Telomere length and brain aging: A systematic review and meta-analysis.

   Ageing Res Rev·2022·n=110Meta-Analysis50 einflussreiche Zitationen

   The current evidence on the association of leukocyte telomere length (LTL) with age-related structural and cognitive changes in the brain is mixed. Herein conforming to PRISMA 2020 guidelines, we performed a systematic review and…

   Befund: No significant association of leukocyte telomere length with brain white matter hyperintensities was detected.

8. 08

   Air pollution and telomere length in adults: A systematic review and meta-analysis of observational studies.

   Environ Pollut·2019·n=19Meta-Analysis45 einflussreiche Zitationen

   Telomere length (TL) has been suggested to be a surrogate for cellular ageing, and a record of cumulative inflammation and oxidative stress over life. An emerging body of evidence has associated exposure to air pollution to changes in TL.…

   Befund: Polychlorinated Biphenyls were directly associated with telomere length in the meta-analysis.

9. 09

   Association between TERT promoter mutations and clinical behaviors in differentiated thyroid carcinoma: a systematic review and meta-analysis.

   Endocrine·2020·n=11.382Meta-Analysis42 einflussreiche Zitationen

   Background The association between telomerase reverse transcriptase ( TERT ) promoter mutations and some clinical behaviors in thyroid cancer remains controversial and requires additional investigation. This study aimed to evaluate the…

10. 10

    Physical Activity on Telomere Length as a Biomarker for Aging: A Systematic Review.

    Sports Med Open·2022·n=43Systematic Review41 einflussreiche Zitationen

    Background Overall life expectancy continues to rise, approaching 80 years of age in several developed countries. However, healthy life expectancy lags far behind, which has, in turn, contributed to increasing costs in healthcare. One way…

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