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Longevity

NMN / NRStudienlage & Dosis

NAD+-Vorläufer, Aging und Bioverfügbarkeits-Vergleich.

Studien zuletzt aktualisiert

Studienlage in Zahlen

Studien gesamt
135
Mit Abstract
47
Meta / Systematic / RCT
50
Häufig zitiert
34
Erscheinungsjahre
2007–2026

NMN / NR im Kontext von Longevity

Dieses Thema ist Teil unserer Welt „Longevity". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Longevity

Top-Studien zu NMN / NR

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

  1. Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.

    Ann Rheum Dis2023n=148Systematic Review138 einflussreiche Zitationen

    <h4>Objective</h4>To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…

  2. Efficacy and safety of non-pharmacological and non-biological interventions: a systematic literature review informing the 2022 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis.

    Ann Rheum Dis2023n=107Systematic Review127 einflussreiche Zitationen

    <h4>Objective</h4>To update the evidence of non-biological treatments for axial spondyloarthritis (axSpA), as a basis for the 2022 Assessment of SpondyloArthritis international Society-European Alliance of Associations for Rheumatology…

  3. Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis.

    Arthritis Res Ther2016n=347Meta-Analysis98 einflussreiche Zitationen

    <h4>Background</h4>Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in ankylosing spondylitis (AS) and non-radiographic axial…

  4. Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis.

    Ann Rheum Dis2015n=309Meta-Analysis70 einflussreiche Zitationen

    <h4>Objectives</h4>This meta-analysis investigates the efficacy of tumour necrosis factor α (TNFα) blockers versus placebo for the treatment of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis…

    Befund: After adjustment for publication year as a proxy for disease severity, the meta-analysis found no difference between ankylosing spondylitis and nr-axSpA trial effect sizes.

  5. Characteristics and burden of disease in patients with radiographic and non-radiographic axial Spondyloarthritis: a comparison by systematic literature review and meta-analysis.

    RMD Open2019n=60Meta-Analysis68 einflussreiche Zitationen

    Objectives To compare the clinical characteristics, burden of disease (eg, disease activity, function, quality of life), treatment modalities and treatment effect in patients with radiographic and non-radiographic axial Spondyloarthritis…

  6. The prevalence of depression in axial spondyloarthritis and its association with disease activity: a systematic review and meta-analysis.

    Arthritis Res Ther2018n=475Meta-Analysis62 einflussreiche Zitationen

    <h4>Background</h4>Depression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axSpA, (ii)…

  7. rTMS for suppressing neuropathic pain: a meta-analysis.

    J Pain2009n=149Meta-Analysis61 einflussreiche Zitationen

    <h4>Unlabelled</h4>This pooled individual data (PID)-based meta-analysis collectively assessed the analgesic effect of repetitive transcranial magnetic stimulation (rTMS) on various neuropathic pain states based on their neuroanatomical…

  8. Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.

    Nutrients2025D52 einflussreiche Zitationen

    Heart failure represents the terminal stage in the development of many cardiovascular diseases, and its pathological mechanisms are closely related to disturbances in energy metabolism and mitochondrial dysfunction in cardiomyocytes. In…

  9. Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis).

    Cochrane Database Syst Rev2015n=435Meta-Analysis42 einflussreiche Zitationen

    <h4>Background</h4>Axial spondyloarthritis (axSpA) comprises ankylosing spondylitis (radiographic axSpA) and non-radiographic (nr-)axSpA and is associated with psoriasis, uveitis and inflammatory bowel disease. Non-steroidal…

  10. NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.

    Exp Gerontol2020n=154systematic41 einflussreiche Zitationen

    Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of biological processes including energy production, DNA…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?
• Biological DMARDs (bDMARDs), including TNF inhibitors, IL-17 inhibitors, IL-23 inhibitors, and IL-12/23 inhibitors (Not reported) • Non-pharmacological and non-biological pharmacological treatments • Assessment of prevalence of peripheral and extra-articular disease manifestations
Gibt es Sicherheitshinweise zu NMN / NR?
• No new risks were identified with TNFi in observational studies. • Secukinumab and etanercept were associated with increased uveitis risk versus monoclonal TNFi. • Observational data were lacking to confirm long-term IL-17i safety. • Safety outcomes were reviewed, but no specific adverse events were reported in the abstract.

Weitere Themen in Longevity

Zone 2

Niedrig-intensives Cardio — mitochondriale Biogenese, Longevity-Basis.

Rapamycin

mTOR-Inhibition, Langlebigkeits-Studien, Off-Label-Dosierung und Sicherheit.

AMPK Activators

Berberin, Alpha-Liponsäure, energetic stress und Glukose-Modulation.

ApoB

Bessere kardiovaskuläre Risiko-Metrik als LDL-C — moderne Lipidologie.

Autophagie

Zellulärer Selbstabbau — Fasten, Sport, Spermidin als Trigger.

Berberin

Glukose, Lipide, AMPK und GI-Verträglichkeits-Daten.

Biologisches Alter

GrimAge, PhenoAge, DunedinPACE — was Epigenetik-Uhren messen.

Caloric Restriction

CR-Mimetika, Lebensspannen-Forschung und NHP-Studien.

Krebsfrüherkennung

Empfehlungen, Über-Diagnose, Galleri-Tests, Ganzkörper-MRT (kritisch).

Zelluläre Seneszenz

„Zombie-Zellen", SASP, Senolytika-Ansätze.

Kollagen

Haut, Gelenke, Sehnen — Evidenz pro Hydrolysat plus Vitamin C.

Demenz-Prävention

Lifestyle-Faktoren: Bewegung, Schlaf, Hörgesundheit, Vaskuläre Gesundheit.

DEXA-Knochendichte

DEXA-Scan für Knochen + Körperzusammensetzung — Verlauf wichtiger als Einzelwert.

Epigenetische Uhren

Horvath, GrimAge, PhenoAge — was sie messen und nicht messen.

Epigenetik

DNA-Methylierung, Histon-Modifikationen, Umwelteinflüsse auf Genexpression.

Exosomen

Zell-Kommunikation, regenerative Anwendungen, frühes Forschungsfeld.

Genetiktests

Variants, Pharmacogenomik, Limitationen — Methylierung, MTHFR-Mythen.

Glucosamine

Gelenke, UK Biobank Mortalitäts-Studie, Sulfat vs HCl-Formen.

Glycin

Methylierung, Kollagensynthese, Lebensspannen-Hinweise in Tiermodellen.

Griffkraft

Starker Mortalitäts-Prädiktor — einfach messbar, trainierbar.

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