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Longevity

NMN / NREvidence & Dosage

NAD+ precursors, aging, and bioavailability comparison.

Studies last updated

Evidence at a glance

Total studies
135
With abstract
47
Meta / Systematic / RCT
50
Highly cited
34
Publication years
2007–2026

NMN / NR in the context of Longevity

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Top studies on NMN / NR

Ranked by influential-citation count and publication year.

  1. Efficacy and safety of biological DMARDs: a systematic literature review informing the 2022 update of the ASAS-EULAR recommendations for the management of axial spondyloarthritis.

    Ann Rheum Dis2023n=148Systematic Review138 influential citations

    <h4>Objective</h4>To update the evidence on efficacy and safety of biological disease-modifying antirheumatic drugs (bDMARDs) in patients with axial spondyloarthritis (axSpA) to inform the 2022 update of the Assessment of SpondyloArthritis…

  2. Efficacy and safety of non-pharmacological and non-biological interventions: a systematic literature review informing the 2022 update of the ASAS/EULAR recommendations for the management of axial spondyloarthritis.

    Ann Rheum Dis2023n=107Systematic Review127 influential citations

    <h4>Objective</h4>To update the evidence of non-biological treatments for axial spondyloarthritis (axSpA), as a basis for the 2022 Assessment of SpondyloArthritis international Society-European Alliance of Associations for Rheumatology…

  3. Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis.

    Arthritis Res Ther2016n=347Meta-Analysis98 influential citations

    <h4>Background</h4>Peripheral disease (arthritis, enthesitis and dactylitis) and extra-articular disease (uveitis, psoriasis and inflammatory bowel disease) is common in ankylosing spondylitis (AS) and non-radiographic axial…

  4. Efficacy of TNFα blockers in patients with ankylosing spondylitis and non-radiographic axial spondyloarthritis: a meta-analysis.

    Ann Rheum Dis2015n=309Meta-Analysis70 influential citations

    <h4>Objectives</h4>This meta-analysis investigates the efficacy of tumour necrosis factor α (TNFα) blockers versus placebo for the treatment of ankylosing spondylitis (AS) and non-radiographic axial spondyloarthritis…

    Finding: After adjustment for publication year as a proxy for disease severity, the meta-analysis found no difference between ankylosing spondylitis and nr-axSpA trial effect sizes.

  5. Characteristics and burden of disease in patients with radiographic and non-radiographic axial Spondyloarthritis: a comparison by systematic literature review and meta-analysis.

    RMD Open2019n=60Meta-Analysis68 influential citations

    Objectives To compare the clinical characteristics, burden of disease (eg, disease activity, function, quality of life), treatment modalities and treatment effect in patients with radiographic and non-radiographic axial Spondyloarthritis…

  6. The prevalence of depression in axial spondyloarthritis and its association with disease activity: a systematic review and meta-analysis.

    Arthritis Res Ther2018n=475Meta-Analysis62 influential citations

    <h4>Background</h4>Depression is common among patients with axial spondyloarthritis (axSpA), but reports of its prevalence are highly variable. We performed a systematic review to (i) describe the prevalence of depression in axSpA, (ii)…

  7. rTMS for suppressing neuropathic pain: a meta-analysis.

    J Pain2009n=149Meta-Analysis61 influential citations

    <h4>Unlabelled</h4>This pooled individual data (PID)-based meta-analysis collectively assessed the analgesic effect of repetitive transcranial magnetic stimulation (rTMS) on various neuropathic pain states based on their neuroanatomical…

  8. Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.

    Nutrients2025D52 influential citations

    Heart failure represents the terminal stage in the development of many cardiovascular diseases, and its pathological mechanisms are closely related to disturbances in energy metabolism and mitochondrial dysfunction in cardiomyocytes. In…

  9. Non-steroidal anti-inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and non-radiographic axial spondyloarthritis).

    Cochrane Database Syst Rev2015n=435Meta-Analysis42 influential citations

    <h4>Background</h4>Axial spondyloarthritis (axSpA) comprises ankylosing spondylitis (radiographic axSpA) and non-radiographic (nr-)axSpA and is associated with psoriasis, uveitis and inflammatory bowel disease. Non-steroidal…

  10. NAD+ therapy in age-related degenerative disorders: A benefit/risk analysis.

    Exp Gerontol2020n=154systematic41 influential citations

    Nicotinamide adenine dinucleotide (NAD+) is an essential pyridine nucleotide that is present in all living cells. NAD+ acts as an important cofactor and substrate for a multitude of biological processes including energy production, DNA…

Frequently asked

What dosage was studied?
• Biological DMARDs (bDMARDs), including TNF inhibitors, IL-17 inhibitors, IL-23 inhibitors, and IL-12/23 inhibitors (Not reported) • Non-pharmacological and non-biological pharmacological treatments • Assessment of prevalence of peripheral and extra-articular disease manifestations
Are there safety considerations for NMN / NR?
• No new risks were identified with TNFi in observational studies. • Secukinumab and etanercept were associated with increased uveitis risk versus monoclonal TNFi. • Observational data were lacking to confirm long-term IL-17i safety. • Safety outcomes were reviewed, but no specific adverse events were reported in the abstract.

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