Longevity

MitophagieStudienlage & Dosis

Spezifische Autophagie für Mitochondrien — Erhalt zellulärer Energie.

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 48
Meta / Systematic / RCT: 0
Häufig zitiert: 4
Erscheinungsjahre: 2003–2026

Mitophagie im Kontext von Longevity

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Top-Studien zu Mitophagie

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

PINK1/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products.
Cell Death Dis2023Study127 einflussreiche Zitationen
Osteoblast apoptosis plays an important role in age-related bone loss and osteoporosis. Our previous study revealed that advanced oxidation protein products (AOPPs) could induce nicotinamide adenine dinucleotide phosphate oxidase…
Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation
Journal of Advanced Research202660 einflussreiche Zitationen
<h4>Introduction</h4>Aged tendon exhibits impaired regenerative capacity due to the accumulation of senescent tendon stem/progenitor cells (TSPCs), which secrete senescence-associated secretory phenotype (SASP) factors and display…
FB1 causes barrier damage to vascular endothelial cells through ferroptosis by a PINK1/Parkin mediated mitophagy-dependent mechanism.
Chem Biol Interact202531 einflussreiche Zitationen
Fumonisin B1 (FB1) is an environmental mycotoxin produced mainly by fungi of the genus Fusarium. Exposure to FB1 can lead to pulmonary edema in pigs, likely caused by damage to vascular endothelial cells, but the mechanism of FB1-induced…
α‑ketoglutarate protects against septic cardiomyopathy by improving mitochondrial mitophagy and fission.
Mol Med Rep2025Study26 einflussreiche Zitationen
Septic cardiomyopathy is a considerable complication in sepsis, which has high mortality rates and an incompletely understood pathophysiology, which hinders the development of effective treatments. α‑ketoglutarate (AKG), a…
Sirtuin 1 Activation Mitigates Murine Vasculitis Severity by Promoting Autophagy and Mitophagy.
bioRxiv : the preprint server for biology2025E1 einflussreiche Zitationen
Sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase, regulates cardiovascular inflammation by modulating cellular stress, inhibiting NLRP3 activation, and promoting the clearance of damaged mitochondria. However, its precise role in…
Autophagy: mechanisms, roles in human diseases, and therapeutic perspectives.
Frontiers in cell and developmental biology2026
Autophagy, a conserved intracellular degradation and recycling process, maintains cellular homeostasis by eliminating damaged organelles, misfolded proteins, and invading pathogens. Dysregulation of autophagy either excessive or…
Antioxidant Proline Carbon Dot-Composited Poly(L-methionine) Hydrogel Restores Mitophagy to Alleviate Cellular Senescence in Intervertebral Disc Degeneration.
Advanced materials (Deerfield Beach, Fla.)2026E
The senescence of nucleus pulposus cells (NPCs) is a hallmark pathological feature of intervertebral disc degeneration. Senescent NPCs exhibit mitochondrial dysfunction and impaired mitophagy, thus compromising mitochondrial turnover and…
Deficiency of LAMP2A in macrophages accelerates hypoxia-induced atherosclerosis by inhibiting BNIP3-mediated mitophagy.
International immunopharmacology2026E
Chaperone-mediated autophagy (CMA) is a critical biological process responsible for degrading proteins in lysosomes. Our previous studies demonstrated that impaired CMA in macrophages accelerated atherosclerosis under normoxic conditions.…
Targeted degradation of aberrant Tau for the discovery of Pulsatilla chinensis in Alzheimer's disease.
Chinese medicine2026E
Alzheimer's disease (AD) is characterized by Tau aggregation, mitochondrial dysfunction, and oxidative stress, yet effective interventions targeting these pathological cascades remain limited. Therapeutic strategies that enhance autophagic…
The 'mitochondrial guardian' α-amyrin links colourful fruit consumption to cognitive resilience.
Autophagy2026E
Mitochondrial quality control is essential for maintaining neuronal function and resilience during aging, yet pharmacological strategies that effectively restore mitophagy to maintain mitochondrial homeostasis remain limited. Emerging…

Häufige Fragen

Welche Dosierung wurde in den Studien untersucht?

• Rapamycin to activate PINK1/Parkin-mediated mitophagy (not reported) • Fumonisin B1 (FB1) exposure; PINK1 siRNA silencing; Ferrostatin-1 treatment (not reported)

Für welche Population gilt die Evidenz?

Die meisten Studien untersuchten: animal.

Gibt es Sicherheitshinweise zu Mitophagie?

• No adverse events reported in the abstract. • FB1 induced barrier damage in vascular endothelial cells. • FB1 triggered ferroptosis and mitophagy-related cellular injury. • Ferrostatin-1 reversed FB1-induced barrier damage and ferroptosis.

Studienlage in Zahlen

Mitophagie im Kontext von Longevity

Top-Studien zu Mitophagie

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