TyrosineEvidence & Dosage
Dopamine/noradrenaline precursor, a stress buffer, cognitive performance under pressure.
Evidence at a glance
- Total studies
- 161
- With abstract
- 45
- Meta / Systematic / RCT
- 2
- Highly cited
- 50
- Publication years
- 1967–2026
Tyrosine in the context of Cognition
This topic is part of our "Cognition" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to CognitionTop studies on Tyrosine
Ranked by influential-citation count and publication year.
Discovery of a Novel, Potent, and Src Family-selective Tyrosine Kinase Inhibitor
Journal of Biological Chemistry1996223 influential citationsHere, we have studied the activity of a novel protein-tyrosine kinase inhibitor that is selective for the Src family of tyrosine kinases. We have focused our study on the effects of this compound on T cell receptor-induced T cell…
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
New England Journal of Medicine2001n=83214 influential citations<h4>Background</h4>BCR-ABL is a constitutively activated tyrosine kinase that causes chronic myeloid leukemia (CML). Since tyrosine kinase activity is essential to the transforming function of BCR-ABL, an inhibitor of the kinase could be…
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
Cancer research2006200 influential citationsStimulation of the insulin and insulin-like growth factor I (IGF-I) receptor activates the phosphoinositide-3-kinase/Akt/mTOR pathway causing pleiotropic cellular effects including an mTOR-dependent loss in insulin receptor substrate-1…
BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.
Oncogene2008200 influential citationsGenetic alterations in the kinase domain of the epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) patients are associated with sensitivity to treatment with small molecule tyrosine kinase inhibitors. Although…
Activation of the AXL kinase causes resistance to EGFR-targeted therapy in lung cancer.
Nature genetics2012n=5200 influential citationsHuman non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire…
Therapeutic advances of targeting receptor tyrosine kinases in cancer.
Signal transduction and targeted therapy2024200 influential citationsReceptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained significant clinical attention in oncology due to their central role in cancer pathogenesis. Genetic alterations, including mutations, amplifications, and…
Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.
The Lancet2005n=73199 influential citations<h4>Background</h4>Human myeloproliferative disorders form a range of clonal haematological malignant diseases, the main members of which are polycythaemia vera, essential thrombocythaemia, and idiopathic myelofibrosis. The molecular…
AXL signaling in cancer: from molecular insights to targeted therapies.
Signal transduction and targeted therapy2025194 influential citationsAXL, a member of the TAM receptor family, has emerged as a potential target for advanced-stage human malignancies. It is frequently overexpressed in different cancers and plays a significant role in various tumor-promoting pathways,…
Tyrosine Kinase Inhibitors in Cancer: Breakthrough and Challenges of Targeted Therapy.
Cancers2020177 influential citationsReceptor tyrosine kinases (RTKs) are key regulatory signaling proteins governing cancer cell growth and metastasis. During the last two decades, several molecules targeting RTKs were used in oncology as a first or second line therapy in…
Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors.
Oncogene2009n=110175 influential citationsThe epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), gefitinib and erlotinib, are reversible competitive inhibitors of the tyrosine kinase domain of EGFR that bind to its adenosine-5' triphosphate-binding site.…
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