MetforminEvidence & Dosage
AMPK activator, TAME study, glucose control, and off‑label use.
Evidence at a glance
- Total studies
- 1,000
- With abstract
- 50
- Meta / Systematic / RCT
- 155
- Highly cited
- 50
- Publication years
- 1990–2026
Metformin in the context of Longevity
This topic is part of our "Longevity" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.
Go to LongevityTop studies on Metformin
Ranked by influential-citation count and publication year.
Diagnosis and Management of Prediabetes: A Review.
JAMA2023n=100meta200 influential citationsIMPORTANCE: Prediabetes, an intermediate stage between normal glucose regulation and diabetes, affects 1 in 3 adults in the US and approximately 720 million individuals worldwide. OBSERVATIONS: Prediabetes is defined by a fasting glucose…
Cardioprotective Glucose-Lowering Agents and Dementia Risk: A Systematic Review and Meta-Analysis.
JAMA Neurol2025n=164,531Meta-Analysis183 influential citations<h4>Importance</h4>Although diabetes is a risk factor for dementia, the effect of glucose-lowering therapy for prevention of incident dementia is uncertain.<h4>Objective</h4>To determine whether cardioprotective glucose-lowering therapy…
Finding: In this meta-analysis of randomized clinical trials, cardioprotective glucose-lowering therapy was not significantly associated with a reduction in cognitive impairment or dementia overall.
Metformin: Is it a drug for all reasons and diseases?
Metabolism2022meta178 influential citationsMetformin was first used to treat type 2 diabetes in the late 1950s and in 2022 remains the first-choice drug used daily by approximately 150 million people. An accumulation of positive pre-clinical and clinical data has stimulated…
Finding: In polycystic ovary syndrome, metformin improves insulin sensitivity.
Inositol is an effective and safe treatment in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials.
Reprod Biol Endocrinol2023n=169meta132 influential citationsBACKGROUND: Metformin is the gold standard insulin sensitizer, which is widely used to treat insulin resistance in polycystic ovary syndrome (PCOS). However, metformin may induce gastrointestinal side effects. OBJECTIVE: Inositols have…
Association of metformin use and cancer incidence: a systematic review and meta-analysis.
J Natl Cancer Inst2024n=166Meta-Analysis96 influential citations<h4>Background</h4>Metformin is among the most widely used antidiabetics medications because of its minimal toxicity, favorable safety profile, availability, and low cost. In addition to its role in diabetes management, metformin may…
Anti-obesity pharmacological agents for polycystic ovary syndrome: A systematic review and meta-analysis to inform the 2023 international evidence-based guideline.
Obes Rev2024n=11Meta-Analysis74 influential citationsThis systematic review and meta-analysis evaluated the efficacy of anti-obesity agents for hormonal, reproductive, metabolic, and psychological outcomes in polycystic ovary syndrome (PCOS) to inform the 2023 update of the International…
Efficacy of adjunctive local periodontal treatment for type 2 diabetes mellitus patients with periodontitis: A systematic review and network meta-analysis.
J Dent2024n=122meta70 influential citationsOBJECTIVES: To investigate the effectiveness of different adjunctive local treatments combined with non-surgical periodontal therapy (NSPT) to reduce pocket depth (PD), gain clinical attachment level (CAL), and/or reduce glycated…
Effects of GLP1RAs on pregnancy rate and menstrual cyclicity in women with polycystic ovary syndrome: a meta-analysis and systematic review.
BMC Endocr Disord2023n=840Meta-Analysis60 influential citationsPurpose This study was aimed to assess the effectiveness of Glucagon-like peptide 1 receptor agonists on pregnancy rate, menses, anthropometric and hormonal parameters in PCOS patients. Methods We conducted searches of the published…
The impact of metformin on weight and metabolic parameters in patients with obesity: A systematic review and meta-analysis of randomized controlled trials.
Diabetes Obes Metab2024n=49Meta-Analysis58 influential citationsThere are conflicting data on the weight-reducing potential of metformin (MTF) in nondiabetic patients with obesity. The purpose of this systematic review and meta-analysis was to evaluate the effect of MTF on weight and cardiometabolic…
Finding: Metformin improved insulin parameters compared with placebo/control, but no effect was detected versus lifestyle modification.
Metformin in pregnancy and childhood neurodevelopmental outcomes: a systematic review and meta-analysis.
Am J Obstet Gynecol2024n=14,042Meta-Analysis54 influential citations<h4>Objective</h4>This study aimed to examine the impact of maternal metformin use during pregnancy on offspring neurodevelopmental outcomes.<h4>Data sources</h4>MEDLINE, Embase, and Web of Science (Core Collection) were searched from…
Finding: Maternal metformin use during pregnancy was not associated with neurodevelopmental delay in infancy.
Frequently asked
What dosage was studied?
Are there safety considerations for Metformin?
Related articles
PCOS and Inositol: What the Meta-Analyses Really Show
Meta-analyses show that Myo-Inositol may improve ovulation and metabolic parameters in PCOS; the benefit versus Metformin is similar, but the evidence remains heterogeneous.
Berberine for Blood Sugar and Insulin Resistance: What the Studies Really Show
Berberine lowers blood sugar and HbA1c moderately in studies, but the evidence is heterogeneous. Here: evidence base, dosage, risks, and comparison with metformin.
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