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Cognition

NoradrenalineEvidence & Dosage

Alertness, attention, the fight-or-flight response.

Evidence at a glance

Total studies
503
With abstract
46
Meta / Systematic / RCT
3
Highly cited
33
Publication years
1958–2026

Noradrenaline in the context of Cognition

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Top studies on Noradrenaline

Ranked by influential-citation count and publication year.

  1. Dimerization and antidepressant recognition at noradrenaline transporter

    Nature202478 influential citations

    The noradrenaline transporter has a pivotal role in regulating neurotransmitter balance and is crucial for normal physiology and neurobiology<sup>1</sup>. Dysfunction of noradrenaline transporter has been implicated in numerous…

  2. Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats.

    Journal of neuroscience research200558 influential citations

    We used intracerebral microdialysis coupled with electrophysiologic recordings to determine relative changes in the concentrations of several neurotransmitters in the medial prefrontal cortex and nucleus accumbens of freely moving rats…

  3. Noradrenaline Modulates Central Amygdala GABA Transmission and Alcohol Drinking in Female Rats

    Biological Psychiatry202650 influential citations

    <h4>Background</h4>Alcohol use disorder (AUD) is a chronic relapsing disorder and a leading preventable cause of death worldwide. The central nucleus of the amygdala (CeA) is a hub for stress and AUD. Norepinephrine (NE), also known as…

  4. Efficacy and acceptability of pharmacological treatments for depressive disorders in primary care: systematic review and network meta-analysis.

    Ann Fam Med2015n=15,161Meta-Analysis44 influential citations

    <h4>Purpose</h4>The purpose of this study was to investigate whether antidepressants are more effective than placebo in the primary care setting, and whether there are differences between substance classes regarding efficacy and…

  5. Network reset: a simplified overarching theory of locus coeruleus noradrenaline function.

    Trends in Neurosciences200541 influential citations

    Unraveling the functional role of neuromodulatory systems has been a major challenge for cognitive neuroscience, giving rise to theories ranging from a simple role in vigilance to complex models concerning decision making, prediction…

  6. Expression cloning of a cocaine-and antidepressant-sensitive human noradrenaline transporter

    Nature199138 influential citations

    At most synapses, chemical signalling is terminated by a rapid reaccumulation of neurotransmitter into presynaptic terminals. Uptake systems for the biogenic amines are the initial site of action for therapeutic antidepressants and drugs…

  7. Noradrenaline‐induced changes in cerebral blood flow in health, traumatic brain injury and critical illness: a systematic review with meta‐analysis

    Anaesthesia202438 influential citations

    <h4>Background</h4>Noradrenaline is a standard treatment for hypotension in acute care. The precise effects of noradrenaline on cerebral blood flow in health and disease remain unclear.<h4>Methods</h4>We systematically reviewed and…

  8. Noradrenaline in the ventral forebrain is critical for opiate withdrawal-induced aversion

    Nature200035 influential citations

    Cessation of drug use in chronic opiate abusers produces a severe withdrawal syndrome that is highly aversive, and avoidance of withdrawal or associated stimuli is a major factor contributing to opiate abuse. Increased noradrenaline in the…

  9. The roles of dopamine and noradrenaline in the pathophysiology and treatment of attention-deficit/hyperactivity disorder.

    Biol Psychiatry2011review34 influential citations

    Through neuromodulatory influences over fronto-striato-cerebellar circuits, dopamine and noradrenaline play important roles in high-level executive functions often reported to be impaired in attention-deficit/hyperactivity disorder (ADHD).…

  10. Epithelium-derived 6-nitrodopamine modulates noradrenaline-induced contractions in human seminal vesicles

    Life Sciences202432 influential citations

    <h4>Aims</h4>To evaluate the basal release of 6-nitrodopamine (6-ND) from human isolated seminal vesicles (HISV) and to characterize its action and origin.<h4>Main methods</h4>Left HISV obtained from patients undergoing prostatectomy…

Frequently asked

Are there safety considerations for Noradrenaline?
• rMAO-As and hypericum extracts had fewer dropouts due to adverse effects. • Adverse-effect discontinuation was a primary outcome.

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