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Methylene BlueEvidence & Dosage

Mitochondria, antimicrobial, and off‑label nootropic use.

Studies last updated

Evidence at a glance

Total studies
714
With abstract
49
Meta / Systematic / RCT
63
Highly cited
50
Publication years
2001–2026

Methylene Blue in the context of Cognition

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Top studies on Methylene Blue

Ranked by influential-citation count and publication year.

  1. Methylene Blue Reduces Mortality in Critically Ill and Perioperative Patients: A Meta-Analysis of Randomized Trials.

    J Cardiothorac Vasc Anesth2024n=556Meta-Analysis69 influential citations

    Vasodilatory hypotension is common in critically ill and perioperative patients, and is associated with adverse outcomes. As a nitric oxide production inhibitor, methylene blue (MB) exerts its vasoconstrictor property and is an adjuvant…

  2. Methylene blue mediated antimicrobial photodynamic therapy in clinical human studies: The state of the art.

    Photodiagnosis Photodyn Ther2020n=5Systematic Review59 influential citations

    <h4>Background</h4>The goal of this study was to update the information about aPDT when using methylene blue (MB) for the treatment of human clinical infections of different etiologies, except for dentistry applications, and to also…

  3. Antimicrobial photodynamic therapy with methylene blue and its derivatives in animal studies: Systematic review.

    Photodermatol Photoimmunol Photomed2024n=261Systematic Review59 influential citations

    <h4>Background</h4>Infections are complications in the wound healing process, and their treatment can lead to antibiotic overuse and bacterial resistance. Antimicrobial photodynamic therapy (aPDT) is used to treat infectious diseases…

  4. Hydroxocobalamin for Vasodilatory Hypotension in Shock: A Systematic Review With Meta-Analysis for Comparison to Methylene Blue.

    J Cardiothorac Vasc Anesth2023n=24Meta-Analysis56 influential citations

    Hydroxocobalamin inhibits nitric oxide-mediated vasodilation, and has been used in settings of refractory shock. However, its effectiveness and role in treating hypotension remain unclear. The authors systematically searched Ovid Medline,…

  5. Methylene blue in anticancer photodynamic therapy: systematic review of preclinical studies.

    Front Pharmacol2023n=10Systematic Review46 influential citations

    Background: Methylene blue has a long history of clinical application. Thanks to phenothiazine chromophore, it has potential in photodynamic anticancer therapy. In spite of the growing body of literature that has evaluated the action of…

  6. Sentinel lymph node biopsy mapped with methylene blue dye alone in patients with breast cancer: A systematic review and meta-analysis.

    PLoS One2018n=18Meta-Analysis43 influential citations

    <h4>Background</h4>Methylene blue dye is easy to obtain in developing countries and can be used in sentinel lymph node mapping for breast cancer. However, the accuracy of methylene blue alone for sentinel lymph node mapping in breast…

  7. Efficacy of antimicrobial photodynamic therapy (aPDT) for nonsurgical treatment of periodontal disease: a systematic review.

    Lasers Med Sci2021n=22Systematic Review42 influential citations

    Although the standard treatment for periodontal disease is based on scaling and root planing (SRP), the use of antimicrobial photodynamic therapy (aPDT) has been studied as a complement to obtain better clinical results. The purpose of…

  8. Methylene Blue in Septic Shock: A Systematic Review and Meta-Analysis.

    Crit Care Explor2024n=302Meta-Analysis42 influential citations

    <h4>Objectives</h4>Although clinicians may use methylene blue (MB) in refractory septic shock, the effect of MB on patient-important outcomes remains uncertain. We conducted a systematic review and meta-analysis to investigate the benefits…

  9. Systematic review of intravenous methylene blue in parathyroid surgery.

    Br J Surg2012n=39Systematic Review39 influential citations

    <h4>Background</h4>Methylene blue is an intraoperative adjunct for localization of enlarged parathyroid glands. The availability of preoperative and other intraoperative localization methods, and the reported adverse effects of methylene…

  10. Antimicrobial photodynamic therapy for the management of gingivitis and white spot lesions in fixed orthodontic patients: A systematic review.

    Int Orthod2024n=12Systematic Review38 influential citations

    <h4>Aim</h4>We conducted this review to evaluate the safety and efficacy of antimicrobial photodynamic therapy (aPDT) for the management of gingivitis and white spot lesions (WSLs) in fixed orthodontic patients.<h4>Methods</h4>The…

Frequently asked

What dosage was studied?
• Methylene blue (MB) • Methylene blue-mediated antimicrobial photodynamic therapy (aPDT) (Methylene blue concentrations 0.0003 to 0.06 molar; pre-irradiation 1 to 5 min; irradiation 8 s to 10 min; irradiance 50 to 750 mW/cm2; radiant exposure 6 to 18 J/cm2) • Antimicrobial photodynamic therapy with methylene blue (MB) or its derivatives (Radiant exposure 12 to 360 J/cm2; MB diluted in saline solution or distilled water; wavelength mainly 630-670 nm)
Are there safety considerations for Methylene Blue?
• Not reported in the abstract. • Adverse events not reported in the abstract. • MB was described as a safe photosensitizer in animal skin lesions. • No adverse events were reported in the abstract.

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