Kognition

SynapsenStudienlage & Dosis

Erregende vs. hemmende Synapsen, LTP/LTD, Lernen auf zellulärer Ebene.

Studienlage in Zahlen

Studien gesamt: 540
Mit Abstract: 43
Meta / Systematic / RCT: 0
Häufig zitiert: 4
Erscheinungsjahre: 1988–2026

Synapsen im Kontext von Kognition

Dieses Thema ist Teil unserer Welt „Kognition". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

Zur Welt Kognition

Top-Studien zu Synapsen

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.
Neuron2001139 einflussreiche Zitationen
Long-term potentiation (LTP) of excitatory transmission in the hippocampus likely contributes to learning and memory. The mechanisms underlying LTP at these synapses are not well understood, although phosphorylation and redistribution of…
Dendritic spine formation and stabilization.
Current opinion in neurobiology200950 einflussreiche Zitationen
Formation, elimination and remodeling of excitatory synapses on dendritic spines represent a continuous process that shapes the organization of synaptic networks during development. The molecular mechanisms controlling dendritic spine…
Synchronous activity of inhibitory networks in neocortex requires electrical synapses containing connexin36.
Neuron200141 einflussreiche Zitationen
Inhibitory interneurons often generate synchronous activity as an emergent property of their interconnections. To determine the role of electrical synapses in such activity, we constructed mice expressing histochemical reporters in place…
Cone bipolar cell synapses generate transient versus sustained signals in parallel ON pathways of the mouse retina
eLife202519 einflussreiche Zitationen
Parallel processing is a fundamental organizing principle in the nervous system and understanding how parallel neural circuits generate distinct outputs from common inputs is a key goal of neuroscience. In the mammalian retina, divergence…
Ultrastructural membrane dynamics of mouse and human cortical synapses
Neuron20262 einflussreiche Zitationen
Live human brain tissues provide unique opportunities for understanding synaptic transmission. Investigations have been limited to anatomy, electrophysiology, and protein localization, while crucial parameters, such as synaptic vesicle…
Synaptic pruning following NMDAR-dependent LTD preferentially affects isolated synapses
iScience20252 einflussreiche Zitationen
Long-term depression (LTD) is an activity-dependent decrease in synaptic strength. This state initiates either a re-potentiation or a loss, aka pruning, of the synapse within hours to days following its induction. However, the precise…
Ionoelastomer Synapses With Configurable Synaptic Plasticity
Advanced Materials20252 einflussreiche Zitationen
An organic heterostructure, composed of an ionoelastomer that comprises polycationic chains and mobile anions, and a semiconducting polymer, forms a new class of artificial synapses. These ionoelastomer synapses update their synaptic…
Single molecule counting detects low-copy glycine receptors in hippocampal and striatal synapses
eLife20261 einflussreiche Zitationen
Glycine receptors (GlyRs) are heteropentameric chloride channels that mediate fast inhibitory neurotransmission in the brainstem and spinal cord, where they regulate motor and sensory processes. GlyRs are clustered in the postsynaptic…
Plastic Arbor: A modern simulation framework for synaptic plasticity—From single synapses to networks of morphological neurons
PLOS Computational Biology20261 einflussreiche Zitationen
Arbor is a software library designed for efficient simulation of large-scale networks of biological neurons with detailed morphological structures. It combines customizable neuronal and synaptic mechanisms with high-performance computing,…
Coincidence detection supported by electrical synapses is shaped by the D-type K+ current
Journal of General Physiology20261 einflussreiche Zitationen
Electrical synapses mediated by gap junctions are widespread in the mammalian brain, playing essential roles in neural circuit function. Beyond their role synchronizing neuronal activity, they also support complex computations such as…