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Nutrigenomic NutritionEvidence & Dosage

Personalized nutrition via gene variation: SNPs, methylation, MTHFR, and how genetic profiles inform vitamin and diet strategies.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
49
Meta / Systematic / RCT
87
Highly cited
50
Publication years
2000–2026

Nutrigenomic Nutrition in the context of Methods

This topic is part of our "Methods" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Nutrigenomic Nutrition

Ranked by influential-citation count and publication year.

  1. Applications of Artificial Intelligence, Machine Learning, and Deep Learning in Nutrition: A Systematic Review.

    Nutrients2024Systematic Review200 influential citations

    In industry 4.0, where the automation and digitalization of entities and processes are fundamental, artificial intelligence (AI) is increasingly becoming a pivotal tool offering innovative solutions in various domains. In this context,…

  2. Dietary (poly)phenols and cardiometabolic health: from antioxidants to modulators of the gut microbiota.

    The Proceedings of the Nutrition Society2025D88 influential citations

    (Poly)phenols are plant secondary metabolites widely abundant in plant foods and beverages comprising a very large number of compounds with diverse structure and biological activities. Accumulating evidence indicates that these compounds…

  3. Maternal Lifestyle Factors Affecting Breast Milk Composition and Infant Health: A Systematic Review.

    Nutrients2024n=20Systematic Review63 influential citations

    <h4>Background/objectives</h4>Breast milk is a dynamic, personalized nutrition source, influenced by maternal diet, lifestyle, and environmental factors, which shape its composition and impact infant health. This review synthesizes…

  4. Genetic risk accentuates dietary effects on hepatic steatosis, inflammation and fibrosis in a population-based cohort.

    J Hepatol2024n=21,619other60 influential citations

    BACKGROUND &amp; AIMS: Steatotic liver disease (SLD), characterized by elevated liver fat content (LFC), is influenced by genetics and diet. However, whether diet has a differential effect based on genetic risk is not well-characterized.…

  5. Integrative Roles of Functional Foods, Microbiotics, Nutrigenetics, and Nutrigenomics in Managing Type 2 Diabetes and Obesity.

    Nutrients2025n=335Systematic Review53 influential citations

    Diabetes and obesity are globally prevalent metabolic disorders posing significant public health challenges. The effective management of these conditions requires integrated and personalized strategies. This study conducted a systematic…

  6. Perspective: Challenges for Personalized Nutrition in the Current United States Regulatory Framework and Future Opportunities.

    Advances in nutrition (Bethesda, Md.)2025E44 influential citations

    Personalized nutrition (PN) aims to provide tailored dietary recommendations to improve a person's health outcomes by integrating a multitude of individual-level information and supporting desired behavior changes. The field is rapidly…

  7. Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders.

    Biochemical and biophysical research communications2023D42 influential citations

    Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity and mortality. The variety of metabolic illnesses can be addressed through personalized medicine. The goal of personalized medicine is to give…

  8. Effect of Personalized Nutrition on Dietary, Physical Activity, and Health Outcomes: A Systematic Review of Randomized Trials.

    Nutrients2022n=9Systematic Review39 influential citations

    Personalized nutrition is an approach that tailors nutrition advice to individuals based on an individual’s genetic information. Despite interest among scholars, the impact of this approach on lifestyle habits and health has not been…

  9. Do Personalized Nutrition Interventions Improve Dietary Intake and Risk Factors in Adults With Elevated Cardiovascular Disease Risk Factors? A Systematic Review and Meta-analysis of Randomized Controlled Trials.

    Nutr Rev2025n=15Meta-Analysis39 influential citations

    <h4>Context</h4>Dietary modifications can improve cardiovascular disease (CVD) risk factors. Personalized nutrition (PN) refers to individualized nutrition care based on genetic, phenotypic, medical, behavioral, and/or lifestyle…

    Finding: Effects of personalized nutrition on plasma lipid outcomes were inconsistent.

  10. Gene-lifestyle interaction on risk of type 2 diabetes: A systematic review.

    Obes Rev2019n=66Systematic Review37 influential citations

    Summary The pathophysiological influence of gene‐lifestyle interactions on the risk to develop type 2 diabetes (T2D) is currently under intensive research. This systematic review summarizes the evidence for gene‐lifestyle interactions…

Frequently asked

What dosage was studied?
• Artificial intelligence, machine learning, and deep learning applications in nutrition (Not reported) • Maternal lifestyle factors (diet, physical activity, smoking, supplementation) (Not reported)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Nutrigenomic Nutrition?
• None reported. • Smoking was associated with altered milk composition, including lower osteopontin levels. • Exposure to ochratoxin A raised concerns. • No adverse events reported; the review notes that future clinical studies are needed to validate long-term efficacy and safety.

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