Metabolische FlexibilitätStudienlage & Dosis

Top-Studien zu Metabolische Flexibilität

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Diet and physical exercise as key players to tackle MASLD through improvement of insulin resistance and metabolic flexibility.

   Frontiers in nutrition·202491 einflussreiche Zitationen

   Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has emerged as a prevalent health concern, encompassing a wide spectrum of liver-related disorders. Insulin resistance, a key pathophysiological feature of MASLD, can be…

2. 02

   Identifying strategies to target the metabolic flexibility of tumours.

   Nature metabolism·202051 einflussreiche Zitationen

   Plasticity of cancer metabolism can be a major obstacle to efficient targeting of tumour-specific metabolic vulnerabilities. Here, we identify the compensatory mechanisms following the inhibition of major pathways of central carbon…

3. 03

   Exercise-Induced Muscle-Fat Crosstalk: Molecular Mediators and Their Pharmacological Modulation for the Maintenance of Metabolic Flexibility in Aging.

   Pharmaceuticals (Basel, Switzerland)·202536 einflussreiche Zitationen

   Regular physical activity induces a dynamic crosstalk between skeletal muscle and adipose tissue, modulating the key molecular pathways that underlie metabolic flexibility, mitochondrial function, and inflammation. This review highlights…

4. 04

   Insulin resistance and metabolic flexibility as drivers of liver and cardiac disease in T2DM.

   Diabetes research and clinical practice·202332 einflussreiche Zitationen

   Metabolic flexibility refers to the ability of tissues to adapt their use of energy sources according to substrate availability and energy demands. This review aims to disentangle the emerging mechanisms through which altered metabolic…

5. 05

   Microglial metabolic flexibility: emerging roles for lactate.

   Trends in endocrinology and metabolism·20225 einflussreiche Zitationen

   Microglia, the resident macrophages of the central nervous system (CNS), play important functions in the healthy and diseased brain. In the emerging field of immunometabolism, progress has been made in understanding how cellular metabolism…

6. 06

   Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

   Molecular Metabolism·20194 einflussreiche Zitationen

   <h4>Background</h4>It has been known for close to a century that, on average, tumors have a metabolism that is different from those found in healthy tissues. Typically, tumors show a biosynthetic metabolism that distinguishes itself by…

7. 07

   Pathophysiological role of metabolic flexibility on metabolic health

   Obesity Reviews·20202 einflussreiche Zitationen

   Summary Glucose, fatty acids, and amino acids among others are oxidized to generate adenosine triphosphate (ATP). These fuels are supplied from the environment (through food intake) and internal depots (through lipolysis, glycogenolysis,…

8. 08

   Investigating the Postprandial Metabolome after Challenge Tests to Assess Metabolic Flexibility and Dysregulations Associated with Cardiometabolic Diseases

   Nutrients·20222 einflussreiche Zitationen

   This review focuses on the added value provided by a research strategy applying metabolomics analyses to assess phenotypic flexibility in response to different nutritional challenge tests in the framework of metabolic clinical studies. We…

9. 09

   Metabolic flexibility during sleep

   Scientific Reports·20212 einflussreiche Zitationen

   Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from…

10. 10

    Skeletal muscle metabolism in health and disease: Mechanisms, interventions, and clinical perspectives.

    iScience·20262 einflussreiche Zitationen

    Skeletal muscle is a vital metabolic organ that regulates systemic energy homeostasis by coordinating glucose uptake, fatty acid oxidation, and amino acid metabolism. Its remarkable capacity for dynamic adaptation, termed metabolic…