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PhotobiomodulationEvidence & Dosage

Red light therapy, mitochondria, skin and wound healing.

Studies last updated

Evidence at a glance

Total studies
1,000
With abstract
50
Meta / Systematic / RCT
145
Highly cited
46
Publication years
1988–2026

Photobiomodulation in the context of Methods

This topic is part of our "Methods" world. There you'll find methodology, evidence and the highest-impact levers — plus the order in which they sensibly build on each other.

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Top studies on Photobiomodulation

Ranked by influential-citation count and publication year.

  1. Devices used for photobiomodulation of the brain-a comprehensive and systematic review.

    J Neuroeng Rehabil2024n=97Systematic Review88 influential citations

    A systematic review was conducted to determine the trends in devices and parameters used for brain photobiomodulation (PBM). The revised studies included clinical and cadaveric approaches, in which light stimuli were applied to the head…

  2. Photobiomodulation combination therapy as a new insight in neurological disorders: a comprehensive systematic review.

    BMC Neurol2024n=95Systematic Review73 influential citations

    Preclinical and clinical studies have indicated that combining photobiomodulation (PBM) therapy with other therapeutic approaches may influence the treatment process in a variety of disorders. The purpose of this systematic review was to…

  3. Low-level red-light therapy for myopia control in children: A systematic review and meta-analysis.

    Clinics (Sao Paulo)2024n=685Meta-Analysis73 influential citations

    <h4>Introduction</h4>Low-Level Red-Light (LLRL) Therapy is a safe and natural way to promote healing and reduce inflammation in the body. When it comes to treating myopia in children, LLRL therapy is recent, and its efficacy and safety…

  4. Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis.

    JNCI Cancer Spectr2024n=652Meta-Analysis61 influential citations

    <h4>Background</h4>Considering the persistent nature and higher prevalence of insomnia in cancer patients and survivors compared with the general population, there is a need for effective management strategies. This systematic review and…

  5. Antimicrobial photodynamic therapy with methylene blue and its derivatives in animal studies: Systematic review.

    Photodermatol Photoimmunol Photomed2024n=261Systematic Review59 influential citations

    <h4>Background</h4>Infections are complications in the wound healing process, and their treatment can lead to antibiotic overuse and bacterial resistance. Antimicrobial photodynamic therapy (aPDT) is used to treat infectious diseases…

  6. Evidence-based consensus on the clinical application of photobiomodulation.

    J Am Acad Dermatol2025n=21systematic59 influential citations

    BACKGROUND: There is a lack of evidence-based consensus to assist clinicians in using photobiomodulation (PBM). OBJECTIVE: To create a consensus on the safe and effective use of PBM. METHODS: A systematic literature review of Embase and…

  7. IS THE PHOTOBIOMODULATION THERAPY EFFECTIVE IN CONTROLLING POST-SURGICAL SIDE EFFECTS AFTER THE EXTRACTION OF MANDIBULAR THIRD MOLARS? A SYSTEMATIC REVIEW AND META-ANALYSIS.

    J Evid Based Dent Pract2024n=989Meta-Analysis57 influential citations

    <h4>Objectives</h4>The extraction of third molars is one of the most performed surgical procedures in oral and maxillofacial surgery. Pain, oedema, and trismus are the most frequently complications related in the surgical postoperative…

  8. Photobiomodulation in the aging brain: a systematic review from animal models to humans.

    Geroscience2024n=37Systematic Review55 influential citations

    Aging is a multifactorial biological process that may be associated with cognitive decline. Photobiomodulation (PBM) is a non-pharmacological therapy that shows promising results in the treatment or prevention of age-related cognitive…

  9. High-intensity versus low-level laser in musculoskeletal disorders.

    Lasers Med Sci2024n=704Meta-Analysis55 influential citations

    <h4>Purpose</h4>To evaluate the current evidence comparing low level to high level laser therapy to reveal any superiorities in the treatment of musculoskeletal disorders.<h4>Methods</h4>Five databases were searched till September 2022 to…

  10. Effectiveness of Photobiomodulation in Reducing Pain and Disability in Patients With Knee Osteoarthritis: A Systematic Review With Meta-Analysis.

    Phys Ther2024n=542Meta-Analysis50 influential citations

    <h4>Objective</h4>Photobiomodulation (PBM) is not implemented in routine clinical management for knee osteoarthritis. This study aims to systematically investigate the effects of PBM in patients with knee osteoarthritis, comparing with…

Frequently asked

What dosage was studied?
• Brain photobiomodulation (PBM) devices applied to the head and/or neck • Photobiomodulation (PBM) combination therapy with other treatments (Not reported) • Low-Level Red-Light (LLRL) therapy (Not reported)
Which population does the evidence apply to?
Most studies investigated: unknown.
Are there safety considerations for Photobiomodulation?
• Not reported in the abstract. • No significant difference in adverse effects between LLRL and control. • Short-term safety only; long-term safety requires additional study. • Not reported in the abstract

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