SelankStudienlage & Dosis

Top-Studien zu Selank

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   Effects of a selanylimidazopyridine on the acute restraint stress-induced depressive- and anxiety-like behaviors and biological changes in mice.

   Behavioural brain research·201927 einflussreiche Zitationen

   In the last decades, selenium-containing compounds have received increasing attention due to their various biological and pharmacological properties. In the present study, we investigated the effects of 3-[(4-methoxyphenyl)…

2. 02

   Possible involvement of GABAergic and nitriergic systems for antianxiety-like activity of piperine in unstressed and stressed mice.

   Pharmacological reports : PR·20148 einflussreiche Zitationen

   <h4>Background</h4>An investigation was made to explore the possibility of anxiolytic activity of piperine in unstressed and stressed mice along with the underlying role of nitriergic and GABAergic modulation for the noted activity of…

3. 03

   Efficacy of Peptide Anxiolytic Selank during Modeling of Withdrawal Syndrome in Rats with Stable Alcoholic Motivation

   Bulletin of Experimental Biology and Medicine·20143 einflussreiche Zitationen

   We studied the effects of selank on the development of symptoms of acute 48-h alcohol withdrawal in outbred rats drinking 10 % ethanol as the only source of fluid for 24 weeks. In alcohol-preferring animals (mean daily ethanol intake >5.0…

4. 04

   The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action

   Molecular Immunology·20143 einflussreiche Zitationen

   Previous studies have shown that synthetic tuftsin analogue Selank and its fragments cause a number of alterations in the expression of certain genes involved in inflammation in mouse spleen. In this work we studied the effect of Selank…

5. 05

   Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

   Behavioural Neurology·20171 einflussreiche Zitationen

   It was shown that the anxiolytic effect of Selank is comparable to that of classical benzodiazepine drugs and that the basis of their mechanism of action may be similar. These data suggest that the presence of Selank may change the action…

6. 06

   Selegiline Ameliorates Depression-Like Behavior in Mice Lacking the CD157/BST1 Gene, a Risk Factor for Parkinson's Disease.

   Frontiers in behavioral neuroscience·2017·n=22

   Parkinson's disease (PD), a neurodegenerative disorder, is accompanied by various non-motor symptoms including depression and anxiety, which may precede the onset of motor symptoms. Selegiline is an irreversible monoamine oxidase-B (MAO-B)…

7. 07

   Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

   Frontiers in Pharmacology·2016

   Clinical studies have shown the similarity of the spectrum of physiological effects of Selank and classical benzodiazepines, such as diazepam and phenazepam. These data suggest that there is a similar basis of their mechanism of action. To…

8. 08

   GABA, Selank, and Olanzapine Affect the Expression of Genes Involved in GABAergic Neurotransmission in IMR-32 Cells

   Frontiers in Pharmacology·2017

   Clinical studies have shown that Selank had an anxiolytic effect comparable to that of classical benzodiazepine drugs, which can enhance the inhibitory effect of GABA by allosteric modulation of GABA_A receptors. These data…

9. 09

   Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity.

   Protein Peptide Letters·2018

   <h4>Background</h4>Anxiety and mood disorders are the most abundant mental health problems worldwide. The commonly used in clinical practice anxiolytics are focused on pharmacological modulation of brain GABA receptor system activity. As a…

10. 10

    Selank, Peptide Analogue of Tuftsin, Protects Against Ethanol-Induced Memory Impairment by Regulating of BDNF Content in the Hippocampus and Prefrontal Cortex in Rats

    Bulletin of experimental biology and medicine·2019

    The effects of a peptide anxiolytic Selank synthesized on the basis of the endogenous peptide tuftsin on memory impairment and content of brain-derived neurotrophic factor (BDNF) in brain structures were analyzed in outbred rats receiving…