L-TryptophanStudienlage & Dosis

Top-Studien zu L-Tryptophan

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

1. 01

   The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies.

   Mol Psychiatry·2021·n=10.912Meta-Analysis185 einflussreiche Zitationen

   The importance of tryptophan as a precursor for neuroactive compounds has long been acknowledged. The metabolism of tryptophan along the kynurenine pathway and its involvement in mental disorders is an emerging area in psychiatry. We…

   Befund: In this meta-analysis of 101 studies with 10,912 participants, tryptophan and kynurenine were decreased across major depressive disorder, bipolar disorder, and schizophrenia.

2. 02

   An integrated meta-analysis of peripheral blood metabolites and biological functions in major depressive disorder.

   Mol Psychiatry·2021·n=49Meta-Analysis133 einflussreiche Zitationen

   Major depressive disorder (MDD) is a serious mental illness, characterized by high morbidity, which has increased in recent decades. However, the molecular mechanisms underlying MDD remain unclear. Previous studies have identified altered…

   Befund: The meta-analysis identified 23 metabolites that differed significantly between MDD patients and controls across 46 studies.

3. 03

   Exploring the Etiological Links behind Neurodegenerative Diseases: Inflammatory Cytokines and Bioactive Kynurenines.

   Int J Mol Sci·2020·n=22Systematic Review103 einflussreiche Zitationen

   Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative diseases (NDs), presenting a broad range of symptoms from motor dysfunctions to psychobehavioral manifestations. A common clinical course is the…

4. 04

   Relationship Between the Gut Microbiome, Tryptophan-Derived Metabolites, and Osteoarthritis-Related Pain: A Systematic Review with Meta-Analysis.

   Nutrients·2025·n=756Meta-Analysis103 einflussreiche Zitationen

   <h4>Introduction</h4>Osteoarthritis (OA) is the most prevalent form of arthritis and affects over 528 million people worldwide. Degenerative joint disease involves cartilage degradation, subchondral bone remodeling, and synovial…

   Befund: The meta-analysis found no significant association between the presence of pain in OA and the presence of bacilli of the genus Streptococcus or plasma markers of the tryptophan pathway.

5. 05

   Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota.

   Biomed Pharmacother·2021Systematic Review97 einflussreiche Zitationen

   Metabolic diseases such as obesity, type 2 diabetes mellitus, and hyperlipidemia are associated with the dysfunction of gut microbiota. Traditional Chinese medicines (TCMs) have shown considerable effects in the treatment of metabolic…

6. 06

   Effect of immune activation on the kynurenine pathway and depression symptoms - A systematic review and meta-analysis.

   Neurosci Biobehav Rev·2020·n=315Meta-Analysis71 einflussreiche Zitationen

   Dysregulated kynurenine (KYN) pathway has been implicated in the pathophysiology of depression. In this systematic review, we examined the relationship between kynurenine pathway metabolites (KYN, kynurenic acid KYNA, tryptophan TRP,…

   Befund: In this systematic review and meta-analysis, IFN-α treatment in patients with chronic illnesses was associated with decreased TRP, increased KYN, and increased KYN/TRP ratio.

7. 07

   Brain Versus Blood: A Systematic Review on the Concordance Between Peripheral and Central Kynurenine Pathway Measures in Psychiatric Disorders.

   Front Immunol·2021·n=59Systematic Review70 einflussreiche Zitationen

   Objective Disturbances in the kynurenine pathway have been implicated in the pathophysiology of psychotic and mood disorders, as well as several other psychiatric illnesses. It remains uncertain however to what extent metabolite levels…

8. 08

   The kynurenine pathway in bipolar disorder: a meta-analysis on the peripheral blood levels of tryptophan and related metabolites.

   Mol Psychiatry·2021·n=16Meta-Analysis65 einflussreiche Zitationen

   Growing evidence suggests that a dysregulation of the kynurenine pathway (KP) occurs in bipolar disorder (BD). This systematic review and meta-analysis aimed at assessing the possible differences in peripheral blood levels of KP…

9. 09

   The tryptophan catabolite or kynurenine pathway in schizophrenia: meta-analysis reveals dissociations between central, serum, and plasma compartments.

   Mol Psychiatry·2022·n=281Meta-Analysis64 einflussreiche Zitationen

   The tryptophan catabolite (TRYCAT) pathway is implicated in the pathophysiology of schizophrenia (SCZ) since the rate-limiting enzyme indoleamine-dioxygenase (IDO) may be induced by inflammatory and oxidative stress mediators. This…

   Befund: No significant increase was found in the neurotoxic composite score based on KYN, 3HK, and picolinic, xanthurenic, and quinolinic acid.

10. 10

    The impact of tryptophan supplementation on sleep quality: a systematic review, meta-analysis, and meta-regression.

    Nutr Rev·2022·n=18meta63 einflussreiche Zitationen

    CONTEXT: L-tryptophan (Trp) has been documented to aid sleep, but a systematic compilation of its effect on sleep quality is still limited. OBJECTIVE: We assessed the effect of Trp supplementation on sleep quality via meta-analysis and…

    Befund: Trp supplementation did not affect other sleep components.

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