Hormone

PregnenoloneStudienlage & Dosis

Hormon-Vorläufer, Gedächtnis, Steroid-Kaskade und Sicherheit.

Studien zuletzt aktualisiert 17. Mai 2026

Studienlage in Zahlen

Studien gesamt: 1.000
Mit Abstract: 50
Meta / Systematic / RCT: 61
Häufig zitiert: 50
Erscheinungsjahre: 1970–2026

Pregnenolone im Kontext von Hormone

Dieses Thema ist Teil unserer Welt „Hormone". Dort findest du Methodik, Studienlage und Hebel mit dem größten Effekt — sowie die Reihenfolge, in der sich Hebel sinnvoll aufeinander aufbauen.

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Top-Studien zu Pregnenolone

Sortiert nach einflussreichen Zitationen und Erscheinungsjahr.

Effects of antidepressant treatment on neuroactive steroids in major depression.
Am J Psychiatry1998Clinical Trial121 einflussreiche Zitationen
<h4>Objective</h4>There is evidence from animal studies that fluoxetine may enhance the concentrations of neuroactive steroids. Therefore, the authors investigated whether clinically effective treatment with antidepressants may alter the…
Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3.
Nature structural & molecular biology2025E88 einflussreiche Zitationen
Transient receptor potential channel subfamily M member 3 (TRPM3) is a Ca2+-permeable cation channel activated by the neurosteroid pregnenolone sulfate (PregS) or heat, serving as a nociceptor in the peripheral sensory system. Recent…
Sulfated and unsulfated steroids modulate gamma-aminobutyric acidA receptor function through distinct sites.
Brain research199986 einflussreiche Zitationen
Sulfated and unsulfated neurosteroids such as pregnenolone sulfate, dehydroepiandrosterone sulfate (DHEAS), pregnanolone, and allopregnanolone, modulate ionotropic amino acid neurotransmitter receptors, and may function as endogenous…
5α-Reductase Inhibition Prevents the Luteal Phase Increase in Plasma Allopregnanolone Levels and Mitigates Symptoms in Women with Premenstrual Dysphoric Disorder.
Neuropsychopharmacology2016n=32RCT59 einflussreiche Zitationen
Changes in neurosteroid levels during the luteal phase of the menstrual cycle may precipitate affective symptoms. To test this hypothesis, we stabilized neurosteroid levels by administering the 5α-reductase inhibitor dutasteride to block…
Pregnenolone effects on provoked alcohol craving, anxiety, HPA axis, and autonomic arousal in individuals with alcohol use disorder.
Psychopharmacology (Berl)2023n=43RCT54 einflussreiche Zitationen
<h4>Rationale</h4>Chronic alcohol intake down-regulates GABAergic transmission and reduces levels of neuroactive steroids. These changes are associated with greater stress dysregulation and high alcohol craving which in turn increases…
Identification of gut bacteria reductases that biotransform steroid hormones.
Nature communications2025E53 einflussreiche Zitationen
The metabolism of steroid hormones by the gut microbiome is increasingly recognized as a key factor in human health; however, the specific enzymes mediating these transformations remain largely unidentified. In this study, we identify…
Promiscuous CYP87A enzyme activity initiates cardenolide biosynthesis in plants.
Nature plants2023n=4E52 einflussreiche Zitationen
Cardenolides are specialized, steroidal metabolites produced in a wide array of plant families1,2. Cardenolides play protective roles in plants, but these molecules, including digoxin from foxglove (Digitalis spp.), are better known for…
Serum progesterone is lower in ovarian stimulation with highly purified HMG compared to recombinant FSH owing to a different regulation of follicular steroidogenesis: a randomized controlled trial.
Hum Reprod2024n=112RCT51 einflussreiche Zitationen
<h4>Study question</h4>Does ovarian stimulation with highly purified (hp)-HMG protect from elevated progesterone in the follicular phase compared to recombinant FSH (r-FSH) cycles through a different regulation of follicular…
Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia.
Neuropsychopharmacology2009n=21RCT49 einflussreiche Zitationen
The neurosteroid pregnenolone and its sulfated derivative enhance learning and memory in rodents. Pregnenolone sulfate also positively modulates NMDA receptors and could thus ameliorate hypothesized NMDA receptor hypofunction in…
The multistep oxidation of cholesterol to pregnenolone by human cytochrome P450 11A1 is highly processive.
The Journal of biological chemistry2024E45 einflussreiche Zitationen
Cytochrome P450 (P450, CYP) 11A1 is the classical cholesterol side chain cleavage enzyme (P450scc) that removes six carbons of the side chain, the first and rate-limiting step in the synthesis of all mammalian steroids. The reaction is a…

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Gibt es Sicherheitshinweise zu Pregnenolone?

• Not reported in the abstract. • No adverse events were reported in the abstract. • Pregnenolone was well tolerated. • No specific adverse events were reported in the abstract.